|本期目录/Table of Contents|

[1]张强.阿奇霉素联合辛伐他汀对慢性阻塞性肺疾病合并肺动脉高压的治疗效果[J].慢性病学杂志,2018,(01):19-21.
　ZHANGQiang.Efficacy of azithromycin combined with simvastatin in the treatment of patients with chronic obstructive pulmonary disease with pulmonary hypertension[J].,2018,(01):19-21.
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阿奇霉素联合辛伐他汀对慢性阻塞性肺疾病合并肺动脉高压的治疗效果(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年01期
页码:
19-21
栏目:
论著
出版日期:
2018-01-30

文章信息/Info

Title:
Efficacy of azithromycin combined with simvastatin in the treatment of patients with chronic obstructive pulmonary disease with pulmonary hypertension
作者:
张强
广东省梅州市五华县人民医院，广东 梅州 514400
Author(s):
ZHANGQiang
Wuhua County People'sHospital,Meizhou,Guangdong514400,China Correspondingauthor:ZHANG Qiang,E-mail:zhangqiangmzs@163.com
关键词:
阿奇霉素; 辛伐他汀; 慢性阻塞性肺疾病; 肺动脉高压
Keywords:
Azithromycin;  Simvastatin;  Chronic obstructive pulmonary disease;  Pulmonary hypertension
分类号:
R563.9
DOI:
-
摘要:
目的 探讨阿奇霉素与辛伐他汀联合治疗慢性阻塞性肺疾病（COPD）合并肺动脉高压的效果，为临床 COPD合并肺动脉高压的治疗提供可靠依据。方法 选取2016年5月—2017年6月广东省梅州市五华县人民医 院收治的178例COPD合并肺动脉高压患者，随机分为观察组和对照组，每组89例。其中，对照组给予常规对症 治疗和辛伐他汀治疗，观察组在对照组的治疗基础上加用阿奇霉素，对比两组的肺收缩压、舒张压、肺功能指标 [6 min步行距离、用力呼气容积（FVE1）和用力肺活量（FVC）]、C反应蛋白（CRP）水平及不良反应等。 结果 治疗6个月后，观察组患者的肺收缩压及舒张压均低于对照组患者（P＜0.05）；观察组患者治疗后的 6 min步行距离比对照组长，且FVC和FEV1均高于对照组（P＜0.05）；治疗后，两组的CRP水平均明显降低， 其中观察组降低幅度比对照组大（P＜0.05）；两组患者均未发生不良反应。结论 阿奇霉素与辛伐他汀的联合 应用有助于降低COPD合并肺动脉高压患者的肺动脉压，改善肺功能，缓解炎症反应，且无不良反应，用药安 全，可提高患者生存质量。
Abstract:
Objective To investigate the efficacy of azithromycin combined with simvastatin in the treat-ment of chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension.Meth-ods Totally178 cases of patients with COPD complicated with pulmonary hypertension were selected from Wuhua County People's Hospital during May 2016 to June 2017, and they were randomly divid-ed into two groups. The control group was given routine symptomatic treatment and simvastatin treat-ment. On the basis of treatment in control group, the observation group was treated with azithromycin. The indexes such as pulmonary systolic pressure, diastolic pressure, pulmonary function（6 min walk-ing distance, FEV1, FVC）, C reactive protein and adverse reactions were observed.Results After 6 months of treatment, compared to the control group, the pulmonary systolic pressure and diastolic pressure were lower（P<0.05）, the 6 min walking distance was longer, and the FVC and FEV1 were higher in the observation group（all P<0.05）. After treatment, the serum C reactive protein lev-els of the two groups were significantly decreased, especially in the observation group （P<0.05）. Pa-tients in two groups did not have adverse reactions. Conclusions The combination of azithromycin and simvastatin can reduce the pulmonary arterial pressure in patients with COPD and pulmonary hyper-tension, improve the pulmonary function, alleviate the inflammatory reaction, and have no adverse reac-tions, can improve the life quality of patients.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：张强，大专，主治医师，研究方向：内科
通信作者：张强，E-mail: zhangqiangmzs@163.com
更新日期/Last Update: 2018-01-30