|本期目录/Table of Contents|

[1]杨敏英,张凌云,李文琪.阿德福韦酯对肝硬化心肌病患者心功能的改善作用[J].慢性病学杂志,2017,(12):1318-1320.
　YANG Min-ying,ZHANG Ling-yun,LI Wen-qi.Effect of adefovir dipivoxil in improving cardiac function in patients with liver cirrhosis and cardiomyopathy[J].,2017,(12):1318-1320.
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阿德福韦酯对肝硬化心肌病患者心功能的改善作用(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2017年12期
页码:
1318-1320
栏目:
论著
出版日期:
2018-01-02

文章信息/Info

Title:
Effect of adefovir dipivoxil in improving cardiac function in patients with liver cirrhosis and cardiomyopathy
作者:
杨敏英; 张凌云; 李文琪
佛山市高明区人民医院感染科，广东佛山528500
Author(s):
YANG Min-ying;  ZHANG Ling-yun;  LI Wen-qi
Department of infectious diseases, people's Hospital of Gaoming District, Foshan 528500, China Corresponding author: YANG Min-ying, E-mail: 29440310@qq.com
关键词:
阿德福韦酯; 慢性乙型肝炎; 肝硬化心肌病
Keywords:
Adefovir dipivoxil;  Chronic hepatitis B;  Liver cirrhosis with cardiomyopathy
分类号:
R183
DOI:
-
摘要:
目的阿德福韦酯作为一种较经济的口服核苷类似物，能强效抑制乙肝病毒复制，改善肝硬化患者肝功 能，本研究探讨其对于乙肝后肝硬化患者心功能的改善作用。方法收集佛山市高明区人民医院2015 年1 月— 2016 年12 月60 例诊断为乙肝后肝硬化患者，随机分为观察组（采用护肝及阿德福韦酯治疗） 和对照组（采用护 肝治疗），每组30 例。测定两组治疗前及治疗后1 年血浆B 型利钠肽（BNP）、天冬氨酸转氨酶（AST）、肌酸激 酶（CK）、肌酸激酶同工酶（CK-MB） 及心脏彩超数据[包括左心房直径、左心室直径、右心室直径及左室射血 分数（EF）]。结果两组治疗1年后监测AST、CK、CK-MB均有下降，差异有统计学意义（P<0.05），且观察组 BNP较治疗前显著下降，差异有统计学意义（P <0.05），对照组较治疗前下降不明显，差异无统计学意义（P >0.05）。 结论阿德福韦酯对乙型肝炎后肝硬化患者应用效果显著，抗乙肝病毒的同时改善了患者心功能及肝功能。
Abstract:
Objective Adefovir dipivoxil is economical and oral nucleoside analogues, and can inhibit the replication of hepatitis B virus effectively, improve liver function in patients with liver cirrhosis. This paper is aimed to investigate the effect of adefovir dipivoxil on improving cardiac function of patients with hepatitis B cirrhosis. Methods A total of 60 cases of patients with hepatitis B cirrhosis were enrolled from Gaoming Dristrict from January 2015 to November 2016, and randomly divided into observation group and control group, each 30 cases. Observation group received basic liver-protecting therapy and adefovir. Control group received basic liver-protecting therapy. Indexes such as N-terminal pronatriuretic peptide （BNP）, serum aspartate aminotransferase （AST）, creatine kinase（CK）, creatine kinase isoenzyme （CK-MB） and echocardiography data were measured，and cardiac color doppler indexes （left atrium diameter, left ventricular diameter, rright ventricular diameter, left ventricular ejection fraction） were observed before treatment and 1 years after treatment. Results After treatment, AST, CK, CK-MB and Right ventricular diameter in the two group were all decreased, and they were statistically significant （all P<0.05）. BNP in the treatment group after treatment was significantly lower than before treatment （P<0.05）, but there was no significant difference of BNP in control group before and after treatment （P>0.05）. There was no significant difference of left atrium diameter, left ventricular diameter, left ventricular ejection fraction between the two groups after treatment （all P> 0.05）. Conclusion Adefovir dipivoxil has a remarkably effect on patients with hepatitis B cirrhosis, and it can improve the cardiac function and liver function.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：佛山市卫生局科研立项（2015399） 作者简介：杨敏英，硕士研究生，主治医师，研究方向：慢性肝病与肝癌的关系 通信作者：杨敏英，E-mail: 29440310@qq.com
更新日期/Last Update: 2017-12-30