|本期目录/Table of Contents|

[1]刘艳霞.苓桂咳喘宁胶囊治疗哮喘急性发作的临床疗效观察[J].慢性病学杂志,2017,(11):1208-1210.
　LIU Yan-xia.Clinical effect of Linggui Kechuanning capsule in the treatment of asthma acute attack[J].,2017,(11):1208-1210.
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苓桂咳喘宁胶囊治疗哮喘急性发作的临床疗效观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2017年11期
页码:
1208-1210
栏目:
论著
出版日期:
2017-11-25

文章信息/Info

Title:
Clinical effect of Linggui Kechuanning capsule in the treatment of asthma acute attack
作者:
刘艳霞
中国中医科学院广安门医院综合科，北京100053
Author(s):
LIU Yan-xia
Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Corresponding author: LIU Yan-xia, E-mail: changyufei9358@163.com
关键词:
苓桂咳喘宁胶囊; 哮喘; 气道炎症; 临床研究
Keywords:
Linggui Kechuanning capsule;  Asthma;  Airway inflammation;  Clinical study
分类号:
R562.2
DOI:
-
摘要:
目的探讨苓桂咳喘宁胶囊治疗哮喘急性发作的临床疗效及对痰液中炎性细胞及细胞因子的影响。方法 选取2016年1月—2017年1月中国中医科学院广安门医院收治的急性哮喘发作患者80例作为研究对象，随机分为 观察组和对照组，每组40 例。其中，对照组采用雾化吸入布地奈德2 ml及沙丁胺醇0.5 ml治疗，2 次/d，观察 组在对照组的治疗基础上给予苓桂咳喘宁胶囊治疗，5 粒/次，3 次/d，7 d 为1 个疗程，两组共治疗2 个疗程。记 录临床症状消失时间（气喘、哮鸣音、咳嗽），采用肺功能仪检测一秒用力呼气容积（FEV1）、呼气峰值流速 （PEF），比较两组临床疗效。结果观察组气喘、哮鸣音、咳嗽消失时间均明显短于对照组，差异均有统计学 意义（t=3.723、4.216、4.432，P<0.05）；对照组和观察组治疗后FEV1、PEF 均较治疗前明显升高，差异有统 计学意义（t=4.355、6.633，3.432、3.634，P<0.05），观察组治疗后FEV1、PEF 明显高于对照组，差异有统计 学意义（t=3.602、3.932，P<0.05）；观察组的临床总有效率为95.00%，明显高于对照组77.50%，差异有统计学 意义（χ2=8.779，P<0.05）。两组患者治疗期间均未见明显不良反应发生。结论苓桂咳喘宁胶囊治疗哮喘急性 发作能有效改善临床临床症状及肺呼吸功能，具有良好的临床应用价值。
Abstract:
Objective To observe the clinical effect of Linggui Kechuanning capsule in the treatment of asthma acute attack and its influence on inflammatory cells and cytokines in sputum. Methods Totally 80 patients with acute asthma attack treated in Guang’anmen Hospital from January 2016 to January 2017 were randomly divided into observation group （n=40） and control group （n=40） . The control group received aerosol inhalation of budesonide 2 ml and salbutamol 0.5 ml, twice a day. The observation group were given Linggui Kechuanning capsule on the basis of treatment in the control group, five tablets each time, three times a day, seven days were taken as a course of treatment. The subjects were all received two courses of treatment. The time of disappearance of clinical symptoms （asthma, wheezing, cough） , the forced expiratory volume （FEV1） and peak expiratory flow （PEF） were collected. The clinical efficacy of the two groups was compared. Results The time of disappearance of clinical symptoms （asthma, wheezing, cough） in observation group were significantly shorter than those in the control group （t=3.723, t=4.216, t=4.432, all P<0.05） . The FEV1 and PEF in the two groups after treatment were significantly higher than those before treatment （t=4.355, t=6.633; t=3.432,t=3.634, all P<0.05） , especially in the observation group （t=3.602, t=3.932, all P<0.05） . The total effective rate of the observation group was 95.00%, which was significantly higher than the control group （total effective rate was 77.50%） , the difference was statistically significant （χ2=8.779,P<0.05） . There was no obviously adverse reaction in the two groups. Conclusion Linggui Kechuanning capsule can improve the clinical symptoms and pulmonary respiratory function and has a good clinical value.

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备注/Memo

备注/Memo:
作者简介：刘艳霞，大学本科，主任医师，研究方向：支气管哮喘、慢性阻塞性肺病、肺源性心脏病等呼吸系统疾病 通信作者：刘艳霞，E-mail: changyufei9358@163.com
更新日期/Last Update: 2017-11-30