|本期目录/Table of Contents|

[1]潘东山,杨水法,杨恩明,等.慢性前列腺炎患者抑郁状态调查及小剂量抗抑郁药物的治疗效果观察[J].慢性病学杂志,2017,(11):1204-1207.
　PAN Dong-shan*,YANG Shui-fa,YANG En-ming,et al.Investigation of depression in patients with chronic prostatitis and effect of low-dose antidepressant drugs[J].,2017,(11):1204-1207.
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慢性前列腺炎患者抑郁状态调查及小剂量抗抑郁药物的治疗效果观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2017年11期
页码:
1204-1207
栏目:
论著
出版日期:
2017-11-25

文章信息/Info

Title:
Investigation of depression in patients with chronic prostatitis and effect of low-dose antidepressant drugs
作者:
潘东山1;  杨水法1;  杨恩明1;  王世先1;  罗广承2
1. 厦门医学院附属医院厦门市第二医院泌尿外科，福建厦门361026； 2. 厦门大学附属中山医院泌尿外科，福建医科大学教学医院，福建厦门361004
Author(s):
PAN Dong-shan*;  YANG Shui-fa; YANG En-ming;  WANG Shi-xian;  LUO Guang-cheng
* Department of Urology, Xiamen Medical School Affiliated Hospital, Xiamen, Fujian 361026, China Corresponding author: LUO Guang-cheng, E-mail: lgch@xmu.edu.cn
关键词:
慢性前列腺炎; 抑郁; 盐酸阿米替林片
Keywords:
Chronic prostatitis;  Depression;  Amitriptyline hydrochloride
分类号:
R697.3
DOI:
-
摘要:
目的分析慢性前列腺炎患者的抑郁状态，评估小剂量抗抑郁药物联合常规药物对伴有抑郁的慢性前列 腺炎患者临床治疗效果，为慢性前列腺炎的临床诊治提供依据。方法选取2014 年3 月至2016 年2 月门诊 1 053 例慢性前列腺炎患者采用Zung 氏抑郁自评量表（SDS） 进行评价。将200 例伴有抑郁状态患者随机双盲分 为试验组和对照组，皆予抗前列腺炎药物（左氧氟沙星片、坦索罗辛缓释片、塞来昔布片），试验组加小剂量阿 米替林，疗程4周。比较两组治疗前后4周国际前列腺炎症状指数表（NIH-CPSI）、SDS 评分。结果1 053例 慢性前列腺炎患者伴有抑郁症状208 例（19.76%），其中轻度129 例（12.25%）、中度65 例（6.17%）、重度14 例 （1.33%）。对照组抑郁症状缓解率27.08%，慢性前列腺炎症状缓解率37.50%，试验组分别为85.71%和87.75%， 差异均有统计学意义（χ2分别为67.55 和52.21，均P<0.05）。结论慢性前列腺炎患者存在较高的抑郁发生率， 联合小剂量抗抑郁药物可明显提高慢性前列腺炎患者的治疗效果。
Abstract:
Objective To investigate depression status in patients with chronic prostatitis and observe the clinical effect of low- dose antidepressant drugs, and to provide a clinical basis for diagnosis and treatment of chronic prostatitis. Methods From Mar. 2014 to Feb. 2016, 1 053 outpatients with chronic prostatitis were evaluated by Zung's self rating depression scale （SDS） . Two hundred patients with depression were randomly divided into two groups, and both groups were treated with anti prostatitis drugs, such as levofloxacin, tamsulosin, celecoxib. The experimental group was given low- dose amitriptyline for 4 weeks. The international prostatitis symptom index （NIH- CPSI） and SDS score were compared between the two groups before and after treatment. Results There were 208 cases （19.75%） with depression symptoms in 1 053 chronic prostatitis patients, including 129 mild cases （12.25%） , 65 moderate cases （6.17%） , 14 severe cases （1.33%） . The remission rate of depressive symptoms and chronic prostatitis in the control group was 27.08% and 37.50% respectively, and that in the experimental group was 85.71% and 87.75% respectively, and the differences were statistically significant （χ2=67.55 and 52.21, all P<0.05） . Conclusion The rate of depression is considerably high in chronic prostatitis patients. Combined with low- dose antidepressant drugs can significantly improve the psychiatric symptoms as well as physical symptoms of chronic prostatitis.

参考文献/References:

[1] 戴继灿.介绍美国国立卫生研究院慢性前列腺炎症状及评分指数 (NIH-CPSI).中国男科学杂志,2003,14(1):62.
[2] 张明园. 精神科评定量表手册[M].2 版. 长沙:湖南科学技术出版 社,1998:35-41.
[3] 梁朝朝,张学军,王克孝. 前列腺炎病因学研究进展[J]. 中华泌尿 外科杂志,2003,24(6):426-428.
[4] 陈修德,郑宝钟,金讯波,等. 慢性前列腺炎患者的心理障碍及治 疗[J].中华男科学,2004,10(2):113-114.
[5] Shoskes DA, Berger R, Elmi A, et al. Muscle tenderness in men with chronic prostatitis/chronic pelvic pain syndrome: The chronic prostatitis cohort study [J]. J Urol, 2008,179(2):556-560.
[6] 武立新,梁朝朝,郝宗耀,等. 慢性前列腺炎患者抑郁障碍的调查 分析[J].中华男科学杂志,2006,12(7):583-586.
[7] 江山,朱春燕,马季,等. 慢性前列腺炎患者抑郁症状相关因素分 析[J].中华男科学杂志,2012,18(3):212-215.
[8] Clemens JQ, Brown SO, Calhoun EA. Mental health diagnoses in patients with interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome: a case/control study [J]. J Urol, 2008,180(4):1378- 1382.
[9] Magri V, Restelli A, Marras E, et al. A severely symptomatic case of anaerobic chronic bacterial prostatitis successfully resolved with moxifloxacin therapy [J]. Anaerobe, 2010,16(3):206-209.
[10] Anothaisintawee T, Attia J, Nickel JC, et al. Management of chronic prostatitis/chronic pelvic pain syndrome: a systematic review and network meta- analysis [J]. JAMA, 2011,305(1):78-86.
[11] 那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南[M]. 北京:人民卫生出版社,2014:448.
[12] 曾晓勇,叶章群,杨为民,等.塞来昔布治疗ⅢA 型慢性前列腺炎的 临床评估[J].中华男科学杂志,2004,10(4):278-281.
[13] 邓春华,邱少鹏,梁宏,等.帕罗西汀佐治慢性前列腺炎63例[J].新 医药,2000,10(31):599.
[14] 张军杰.盐酸坦洛新缓释胶囊联合阿米替林治疗慢性非细菌性前 列腺炎[J].中国临床研究,2012,2(25):263-264.
[15] 蔡岳斌,钟惟德,王良圣,等. 帕罗西汀治疗病原体阴性慢性前列 腺炎35例疗效观察[J].新医学,2001,32(3):156.
[16] 庞军,石捷,蒙大平,等. 曲唑酮治疗伴焦虑症状慢性前列腺炎的 对照研究[J].中国性科学,2012,21(7):21.

备注/Memo

备注/Memo:
作者简介：潘东山，硕士研究生，副主任医师，研究方向：前列腺疾病，泌尿系结石 通信作者：罗广承，E-mail：lgch@xmu.edu.cn
更新日期/Last Update: 2017-11-30