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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

期数:

2017年10期

页码:

1108-1110

栏目:

论著

出版日期:

2017-11-05

文章信息/Info

Title:

Clinical value of diagnostic and prognosis assessment of pro gastrin-releasing peptide for small cell lung cancer

作者:

林玉梅;  李新才;  黄超林;  戴庆福

福建医科大学附属龙岩第一医院，福建省龙岩市第一医院中心实验室，福建龙岩364000

Author(s):

LIN Yu-mei;  LI Xin-cai;  HUANG Chao-lin;  DAI Qing-fu

The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian 364000, China Corresponding author: DAI Qing-fu, E-mail: liudeqiang0324@163.com

关键词:

小细胞肺癌; 胃泌素释放肽前体; 神经元特异性烯醇化酶

Keywords:

Small cell lung cancer;  Gastrin release peptide precursor;  Neuron-specific enolase

分类号:

R734.2

DOI:

-

摘要:

目的探讨小细胞肺癌（SCLC） 患者血清胃泌素释放肽前体（Pro-GRP） 的水平及意义。方法回顾 分析60例SCLC 患者和120例肺部良性病变患者的临床病理资料，分别作为SCLC 组和良性组；同期体检健康者 100 例作为对照组。所有入组对象均进行血清Pro-GRP 和神经元特异性烯醇化酶（NSE） 检测，比较组间差 异；以阳性标准Pro-GRP>77.8 pg/ml，NSE>16.3 ng/ml 判断，比较不同诊断方法的灵敏度、特异度；比较 SCLC 患者不同分期及不同治疗效果患者Pro-GRP、NSE 水平差异。结果SCLC 组血清Pro-GRP、NSE 明 显高于良性组和健康组（P<0.05）。Pro- GRP 诊断SCLC 的灵敏度为80.00%，高于NSE （P<0.05），Pro- GRP + NSE 诊断SCLC 的灵敏度为98.33%，高于Pro- GRP、NSE （P<0.05）。SCLC 广泛期患者Pro- GRP、 NSE 高于SCLC 局限期（P<0.05）；SCLC 治疗后缓解期、好转期的Pro-GRP、NSE 低于治疗前，且缓解期低 于好转期（P<0.05）；治疗后进展期患者Pro-GRP、NSE 高于治疗前（P<0.05）。结论SCLC 患者血清Pro- GRP 水平呈高表达，其诊断SCLC 的灵敏度高于NSE，并与肿瘤的分期及预后存在相关性。

Abstract:

Objective To investigate the clinical value of diagnostic and prognosis assessment of pro gastrin-releasing peptide （Pro-GRP） for small cell lung cancer （SCLC） . Methods Totally 60 cases of SCLC （SCLC group） and 120 cases of benign lung lesions （benign group） were analyzed retrospectively, and 100 healthy were selected as control group. and the pro gastrin- releasing peptide （Pro- GRP） and neuron-specific enolase （NSE） were detected and compared between the three groups. The sensitivity and specificity of Pro-GRP and NSE were analyzed with the positive standard Pro-GRP> 77.8 pg/ml, NSE>16.3 ng/ml. The differences of Pro- GRP and NSE levels in different stages and different therapeutic effects of SCLC patients were compared. Results The levels of Pro- GRP and NSE in SCLC group were significantly higher than those in benign group and control group （P< 0.05） . The sensitivity of Pro-GRP were 80.00%, which was higher than NSE in diagnosis of SCLC （P<0.05） . The sensitivity of Pro- GRP combined with NSE in diagnosis of SCLC was 98.33% , which was significantly higher than that of Pro- GRP and NSE （P<0.05） . The levels of Pro- GRP and NSE in SCLC patients of extensive period were significantly higher than those in SCLC patients of limited period （P<0.05） . After treatment, the levels of Pro-GRP and NSE in SCLC patients of remission stage and improvement period were significantly decreased （P<0.05） , and the remissionstage was lower than the improvement period （P<0.05） . After treatment, the levels of Pro-GRP and NSE in the SCLC patients of progress period were significantly increased than those before treatment （P<0.05） . Conclusion Pro-GRP is high expression in SCLC patients and correlated with the stage and prognosis of SCLC, and its sensitivity for SCLC is higher than NSE.

参考文献/References:

[1] 钟润波,韩宝惠,苗茜.IEP化疗后予EP维持治疗广泛期小细胞肺 癌的临床研究[J].中国癌症杂志,2009,10(19):774-778.
[2] 张家祺,王迎难,李强.胃泌素释放肽前体在小细胞肺癌诊断及预 后的临床价值[J].国际肿瘤学杂志,2007,34(3):216-218.
[3] 瞿介明,曹彬.中国成人社区获得性肺炎诊断和治疗指南(2016年 版)修订要点[J].中华结核和呼吸杂志,2016,39(4):253-279.
[4] 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2016 年版)[J].中华结核和呼吸杂志,2016,39(9):675-697.
[5] 阿布都卡地尔·阿布力米提. 慢性支气管炎的治疗指南[J]. 新疆 维吾尔医学专科学校学报,2016,26(4):102-103.
[6] 戴元荣,许瑞玉,吴立琴.2010 年欧洲结核病治疗指南解读[J]. 浙 江医学,2011,33(6):789-790.
[7] 王薇,蔡柏蔷. 解读英国胸科学会与澳大利亚、新西兰和爱尔兰 胸科学会联合制定的间质性肺疾病指南[J].国际呼吸杂志,2009, 29(14):833-836.
[8] 王静静,陈梅莉,钱震东,等. 小细胞肺癌患者胃泌素释放肽前体 表达的临床意义[J].实用医学杂志,2016,32(11):1784-1787.
[9] 张晓伟,丛占杰,朱华,等. 胃泌素释放肽前体与神经元特异性烯 醇化酶在小细胞肺癌诊断及预后中的价值[J]. 中国实验诊断学, 2017,21(1):89-91.

备注/Memo

备注/Memo:

作者简介：林玉梅，大学本科，主管技师，主要从事肿瘤标记物临床研究 通信作者：戴庆福，E-mail：liudeqiang0324@163.com

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更新日期/Last Update: 2017-10-30