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[1]王睿,黄华杰,林进爵.高血压患者同型半胱氨酸水平与轻度认知功能损伤的相关性研究[J].慢性病学杂志,2017,(07):724-726.
　WANG Rui,HUANG Hua-jie,LIN Jin-jue.Association between plasma homocysteine and the mild cognitive impairment in patients with hypertension[J].,2017,(07):724-726.
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高血压患者同型半胱氨酸水平与轻度认知功能损伤的相关性研究(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2017年07期
页码:
724-726
栏目:
论著
出版日期:
2017-08-08

文章信息/Info

Title:
Association between plasma homocysteine and the mild cognitive impairment in patients with hypertension
作者:
王睿; 黄华杰; 林进爵
遂溪县人民医院，广东遂溪524300
Author(s):
WANG Rui;  HUANG Hua-jie;  LIN Jin-jue
Suixi County People's Hospital, Suixi, Guangdong 524300, China Corresponding author: WANG Rui, E-mail: 67797245@qq.com
关键词:
同型半胱氨酸; 高血压; 轻度认知功能损伤
Keywords:
Plasma homocysteine;  Hypertension;  Mild cognitive impairment
分类号:
R544.1
DOI:
-
摘要:
目的探讨高血压患者血浆同型半胱氨酸（Homocysteine，Hcy） 水平与轻度认知功能损伤（Mild Cognitive Impairment，MCI） 的相关性。方法选取2012年3月—2014年3月遂溪县人民医院内科住院的高血 压患者186 例，Hcy等相关生化指标均由检验科按标准流程检测，按三分位将Hcy分为低Hcy组、中Hcy组及高 Hcy组，采用logistic回归模型对Hcy水平与MCI相关性进行探讨。结果高Hcy组中MCI患者比例明显高于其 他两组（45.16%、30.65%和17.74%，P=0.04），进一步使用logistic 回归模型对二者相关性进行探讨，对相关危 险因素进行校正后发现高Hcy 组较低Hcy 组患者MCI 的风险明显增加[OR （95%CI） 为3.81 （1.43~8.66），P= 0.017]。结论高血压患者Hcy 水平高者较Hcy 水平低者发生MCI的风险有所增加，血浆Hcy 水平可能是MCI 危险因素之一。
Abstract:
Objective To investigate the association between plasma homocysteine and the mild cognitive impairment of hypertension patients. Methods Totally 186 hypertension cases were enrolled from March 2012 to March 2014 in the Suixi County People's Hospital. The biochemistry items such as Hcy were detected by standard procession. Subjects were divided into high Hcy group, medium Hcy group and low Hcy group by Tertile analysis. The relationship between plasma Homocysteine and MCI was demonstrated by logistic regression analysis. Results The proportion of MCI in high group was much higher than those in medium Hcy group and low Hcy group （45.16% vs. 30.65% vs. 17.74%, P=0.04). Logistic regression analysis indicated that patients were in high Hcy goup had higher risk compared with low Hcy group [OR （95%CI): 3.81 （1.43-8.66), P=0.017]. Conclusions Hypertension patients with high plasma Hcy level has higher MCI risk than those patients with low Hcy level. Serum Hcy level was one of the related risk factor of MCI.

参考文献/References:

[1] 董智瑀,李云霞.高血压与认知功能障碍[J].转化医学杂志,2016, 5(5):308-310.
[2 Viswanathan A, Rocca WA, Tzourio C. Vascular risk factors and dementia: how to move forward [J]. Neurology, 2009,72(4):368-374.
[3] Sally SI, Aarsland D, Day S, et al. Hypertension is a po-tential risk factor for vascular dementia: systematic review [J]. Int J Geriatr Psychiatry, 2011,26(7):661-669.
[4] Dufouil C, Alperovitch A, Ducros V, et al. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people [J]. Ann Neurol, 2003,53(2):214-221.
[5] Saehdev E. Homecysteine and neumpsychiatric disorders [J]. Rev Bras Psiquiatr, 2004,26(1):50-60.
[6] Kocer B, Guven H, Conkbayir I, et al. The Effect of Hyperhomocysteinemia on Motor Symptoms, Cognitive Status, and Vascular Risk in Patients with Parkinson's Disease [J]. Parkinsons Dis, 2016,10:1589747.
[7] 高风超,陈翔,田新英.血管性痴呆危险因素及发病机制的研究进 展[J].医学综述,2014,20(6):1068-1071.
[8] Nagai M, Hoshide S. Kario K. Hypertension and Dementia [J]. Am J Hypertens, 2010,23(2):116-124.
[9] Sally SI, Aarsland D, Day S, et al. Hypertension is a potential risk factor for vascular dementia: systematic review [J]. Int J Geriatr Psychiatry, 2011,26(7):661-669.
[10] Gorgon G, Ursini F, Altamura C, et al. Hyperhomocysteinemia, intima- media thickness and C677T MTHFR gene polymorphism: A correlation study in patients with cognitive impairment [J]. Atherosclerosis, 2009,106(1):309-313.
[11] Dufouil C, Alperovitch A, Ducros V, et al. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people [J]. Ann Neurol, 2003,53(2):214-221.
[12] Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease [J]. Am J Clin Nutr, 2005,82(3):636-643.
[13] 李燕,张春来,卢峰,等. 高同型半胱氨酸血症对平滑肌细胞的氧 化损伤[J].首都医科大学学报,2012,33(2):251-254.
[14] Inzitari D, LamassaM, PantoniL, et al. Therapy of vascular dementia [J]. Arch Gerontol Geriatr, 2004,9(suppl):229- 234.
[15] Kruman II, Culmsee C, Chan SL, et al. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hyper sensitivity to exitotoxicity [J]. Neurosci Res, 2000,20(2):6920-6926.
[16] Gortz P, Hoinkes A, Fleischer W, et al. Implications fohyperhomocysteinemia: Not homocysteine but its oxidized forms strongly inhibit neuronal network activity [J]. Neurol Sci, 2004,218(1):109-114.

备注/Memo

备注/Memo:

作者简介：王睿，大学本科，主治医师，研究方向：心血 管内科
通信作者：王睿，E-mail: 67797245@qq.com
更新日期/Last Update: 2017-08-18