|本期目录/Table of Contents|

[1]刘秋燕.正清风痛宁治疗膝骨关节炎临床疗效以及对细胞因子的影响[J].慢性病学杂志,2016,(09):972-975.
　LIU Qiu-yan.Clinical effect of Zhengqing Fengtongning on knee osteoarthritis and its effect on expression of IL-1β and TNF-α[J].,2016,(09):972-975.
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正清风痛宁治疗膝骨关节炎临床疗效以及对细胞因子的影响(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年09期
页码:
972-975
栏目:
论著
出版日期:
2016-10-27

文章信息/Info

Title:
Clinical effect of Zhengqing Fengtongning on knee osteoarthritis and its effect on expression of IL-1β and TNF-α
作者:
刘秋燕
四川省攀枝花煤业集团有限公司总医院，四川攀枝花617000
Author(s):
LIU Qiu-yan
General Hospital of Panzhihua Coal Industry Group Co., Ltd., Sichuan Province, Panzhihua, Sichuan 617000, China Corresponding author: LIU Qiu-yan, E-mail: 13321192663@163.com
关键词:
正清风痛宁; 膝骨关节炎; 血清白细胞介素1β; 肿瘤坏死因子α
Keywords:
Zhengqing Fengtongning;  Knee osteoarthritis;  Interleukin-1β;  Tumor necrosis factor-α
分类号:
R287
DOI:
-
摘要:
目的观察正清风痛宁对膝骨关节炎的临床治疗效果，以及探究对细胞因子白细胞介素1β （IL-1β） 和肿 瘤坏死因子α （TNF-α） 表达的影响。方法选取四川省攀枝花煤业集团有限公司总医院骨科收治的膝骨关节 炎患者80 例作为研究对象，随机分为观察组和对照组，每组40 例。对照组采用盐酸氨基葡萄糖240 mg/次， 2 次/d；观察组采用正清风痛宁60 mg/次，2 次/d。治疗10 周结束时，观察两组患者关节疼痛，僵硬和活动功能 困难程度，检测血清IL-1β 和TNF-α 的表达，以及两组患者不良反应发生率。结果经过10 周治疗，观察组 总有效率为92.50%，对照组总有效率为85.00%，差异有统计学意义（χ2=6.11，P＜0.05）。观察组不良反应发生 率3 例（7.50%），对照组7 例（17.5%），差异有统计学意义（χ2=3.28，P＜0.05）。两组患者疼痛、关节僵硬、活 动度较治疗前改善明显，差异有统计学意义（P＜0.05）；但观察组提高程度高于对照组，差异有统计学意义 （P＜0.05）。两组患者血清IL-1β和TNF-α 与治疗前相比均下降，差异有统计学意义（P＜0.05），且观察组指标 下降幅度大于对照组（P＜0.05）。结论正清风痛宁治疗膝骨关节炎疗效显著，且不良反应较小，同时也降低 了血清IL-1β和TNF-α表达。
Abstract:
Objective To observe the clinical effects of Zhengqing Fengtongning on knee osteoarthritis treatment and expression of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). Methods A total of 80 patients with knee osteoarthritis were included and divided into two groups randomly. The experimental group was treated with Zhengqing Fengtongning 60 mg/times, 2 times/day. The control group was treated with glucosamine hydrochloride 240 mg/times, 2 times/day. The joint pain, stiffness, activities function, IL-1β and TNF-α and side effect after 10 weeks of treatment were evaluated. Results After 10 weeks of treatment, the total effective rate of the observation group was 92.50%; the total effective rate of the control group was 85.00% . The difference between the two groups was statistically significant (χ2=6.11, P<0.05). Adverse reaction occurred in 3 cases (7.50% ) of the observation group and 7 cases (17.5%) in the control group, and the difference was statistically significant (χ2=3.28, P<0.05). The experimental group were improved better than control group in the degree of joint pain, stiffness and activities function (P<0.05). Moreover, the IL-1β and TNF-α were decreased in both groups after 10 weeks treatment (P<0.05), and the experimental group decreased more significantly than the control group (P<0.05).Conclusion Zhengqing Fengtonging is an effective drug on treating knee osteoarthritis with less side effects.

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备注/Memo

备注/Memo:
作者简介：刘秋燕，本科，主治医师，主要从事：骨科临床诊疗工作 通信作者：刘秋燕，E-mail：13321192663@163.com
更新日期/Last Update: 2016-10-27