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[1]孔祥泉,曾毅,王立峰,等.乳腺癌组织中SCUBE2表达与临床病理特征的相关性研究[J].慢性病学杂志,2016,(08):845-849.
　KONG Xiang-quan*,ZENG Yi,WANG Li-feng,et al.Correlation of the expression of SCUBE2 and clinicopathological characteristics in the invasive breast cancer[J].,2016,(08):845-849.
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乳腺癌组织中SCUBE2表达与临床病理特征的相关性研究(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年08期
页码:
845-849
栏目:
论著
出版日期:
2016-09-27

文章信息/Info

Title:
Correlation of the expression of SCUBE2 and clinicopathological characteristics in the invasive breast cancer
作者:
孔祥泉1; 曾毅2; 王立峰1; 马礼钦1; 胡丹3; 林贤东3
福建省肿瘤医院（1. 放疗科；2. 乳腺外科；3. 病理科），福州350014
Author(s):
KONG Xiang-quan*;  ZENG Yi;  WANG Li-feng;  MA Li-qin;  HU Dan;  LIN Xian-dong
* Department of Radiotherapy Oncology, The Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou, Fujian 350014, China Corresponding author: LIN Xian-dong, E-mail: linxdong1970@yeah.net
关键词:
乳腺癌; SCUBE2; 液相芯片; 生长
Keywords:
Breast cancer;  SCUBE2;  Multiplex branched-DNA (bDNA) liquidchip technology;  Development
分类号:
R587.1
DOI:
-
摘要:
目的检测人类细胞表面糖蛋白2 （SCUBE2） 在乳腺癌组织中的表达情况，探讨SCUBE2 表达与乳腺 癌患者临床病理特征及乳腺癌关键基因的相关性。方法应用液相芯片基因检测技术检测152 例乳腺癌组织样 本SCUBE2、Bcl-2、Survivin及PTEN 基因mRNA 表达，分析上述指标与乳腺癌患者临床病理学资料及它们之 间的相关性。结果在乳腺癌中SCUBE2 mRNA 的表达与ER、PR 及Ki67状态密切相关（P＜0.05）；进一步分 析结果显示，中—高表达SCUBE2 的患者Ki67 活跃程度明显低于低表达SCUBE2 的患者（P<0.05）。Survivin mRNA 的表达与Ki67 状态密切相关（P＜0.05）；PTEN mRNA 表达与ER 及PR 状态密切相关（P＜0.05）； Bcl- 2 mRNA 表达与淋巴结转移、ER、PR 及Ki67 状态密切相关（P＜0.05）。Spearsman 等级相关法分析表 明，SCUBE2表达与Bcl-2及PTEN 表达呈正相关（r=0.434、0.348，P<0.01），而SCUBE2表达与Survivin 表 达呈负相关（r=－0.249,P＜0.01）。结论在乳腺癌中SCUBE2 表达与肿瘤增殖密切相关，可能是乳腺癌重要 预后指标。
Abstract:
Objective To evaluate the expression of SCUBE2 of breast cancer and relationship with clinicopathological characteristics and association with Bcl- 2, Survivin and PTENin the invasive breast cancer. Method The expression of SCUBE2, Bcl- 2, Survivin and PTEN in 152 paraffin- embedded tumor tissue was detected by the multiplex branched- DNA (bDNA) liquidchip technology. In addition the relation between expression of SCUBE2 and clinicopathological characteristics and association with Bcl- 2, Survivin and PTEN were analyzed. Result The expression of SCUBE2 in breast cancer was significantly associated with ER, PR and Ki67 (P<0.05). Ki67 activity of patients with medium- high expression SCUBE2 was lower than that of patients with low expression of SCUBE2. The expression of Survivin in breast cancer was significantly associated with Ki67 (P＜0.05). The expression of PTEN in cancer cells was significantly related with ER and PR (P＜0.05). The expression of Bcl- 2 in breast cancer cells was significantly associated with lymphoma metastasis, ER, PR (P＜0.05). Spearsman rank correlation analysis showed that SCUBE2 expression was positively correlated with that of Bcl- 2 and PTEN (r=0.434,0.348, P<0.01) and negatively correlated with that of Survivin (r=－0.249,P＜0.01). Conclusion The expression of SCUBE2 is closely related to tumor development in breast cancer. SCUBE2 might be used as a predictor for prognosis for breast cancer.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：福建省自然科学基金面上项目（2016J01508）；国家临床重点专科建设项目；福建省临床重点专科建设项目； 福建省肿瘤转化医学重点实验室项目 作者简介：孔祥泉，大学本科，副主任医师，研究方向：乳腺癌综合治疗 通信作者：林贤东，E-mail:linxdong1970@yeah.net
更新日期/Last Update: 2016-09-27