|本期目录/Table of Contents|

[1]付路宽.保留乳房手术联合放化疗治疗早期乳腺癌效果观察[J].慢性病学杂志,2016,(04):396-399.
　FU Lu-kuan.Effect of breast-conserving surgery in combination with radiation and chemotherapy therapy on patients with early-stage breast cancer[J].,2016,(04):396-399.
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保留乳房手术联合放化疗治疗早期乳腺癌效果观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年04期
页码:
396-399
栏目:
论著
出版日期:
2016-06-27

文章信息/Info

Title:
Effect of breast-conserving surgery in combination with radiation and chemotherapy therapy on patients with early-stage breast cancer
作者:
付路宽
濮阳市红十字医院，河南濮阳457000
Author(s):
FU Lu-kuan
Red Cross Hospital of Puyang City in Henan province, Henan, Puyang 457000,China Corresponding author: FU Lu-kuan,E-mail:fulukuan1202@163.com
关键词:
保留乳房手术、改良根治术、放疗、化疗
Keywords:
Breast-conserving surgery;  Modified radical surgery;  Radiation therapy;  Chemotherapy
分类号:
R655.8
DOI:
-
摘要:
目的研究保留乳房手术联合放化疗治疗早期乳腺癌对比改良根治术的临床效果。方法选择2010 年1 月-2013 年1 月期间来濮阳市红十字医院检查确诊的56 例早期乳腺癌患者，随机法将随机分为对照 组和试验组两组，每组28 例，对照组患者实施改良根治术，试验组患者实施保乳手术，两组患者术后均进 行化疗及放疗辅助治疗。出院后均进行定期随访与复查，连续3 年，统计两组患者的术后并发症发生率、 局部复发率、远处转移率，以及对患者生活质量采用乳腺癌生存治疗测评量表进行调查。结果对照组皮 瓣坏死3 例， 皮下积液5 例， 局部复发2 例， 远处转移2 例； 3 年内生存25 例； 试验组患者皮瓣坏死1 例，皮下积液2 例，局部复发1 例，远处转移1 例，3 年内生存26 例，两组并发症比较差异有统计学意义 （P＜0.05）；复发率、3 年生存率等比较差异无统计学意义（P＞0.05）。生理状况、社会/家庭情况、情感 状况、附加关注方面试验组评分均明显高于对照组（P＜0.05）； 功能状况两组比较差异无统计学意义 （P＞0.05）。结论患者自身条件达到保留乳房手术指标前提下，实施保留乳房手术，术后并发症低于改良 根治术，复发、转移、3 年生存率相比无差异，并能提高患者术后生活质量，值得临床推广。
Abstract:
Objective To study the clinical effect of breast- conserving surgery combined with radiation and chemotherapy in the treatment of patients with early-stage breast cancer, and compared to the clinical effect of modified radical operation. Methods Fifty-six patients with early-stage breast cancer were selected from patients in our hospital, who was diagnosed during 2010 to 2013, and randomly divided into control group and experimental group, each group of 28 cases. Patients in control group were treated with modified radical operation, patients in experimental group received breast- conserving surgery. After surgery, all patients received radiation and chemotherapy. The rate of complications, local recurrence, distant metastasis were counted. Breast cancer survival treatment assessment scale was used to evaluate life quality after following up for 3 years. Results In the control group, there were 3 cases of skin flap necrosis, 5 cases of subcutaneous effusion, 2 cases of local recurrence and 2 cases of distant metastases. In the all, there were 25 cases of patients survived until the end of follow-up. In experimental group, there were 1 case of skin flap necrosis, 2 cases of patients with subcutaneous effusion, 1 case of local recurrence and 1 case of distant metastasis. Totally 26 cases of patients survived after 3 years of follow- up. The complications rate between the two groups were statistically significant (P< 0.05); The recurrence rate, 3 years of productivity were not significant(P>0.05). Physiology, social/fami-ly situation, emotional state, additional attention score in the experimental group were significantly higher than those in control group (all P<0.05), function score in two groups was no significant difference(P> 0.05). Conclusions On the basis of the patient's own condition to reach the standard of breast surgery, breast-conserving surgery can make complications rate decreased, life quality improved, in comparison to modified radical operation, but there are no difference in metastasis, recrudesce, and 3 years of surviving rate.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：付路宽，大学本科，主治医师，主要研究方向：乳腺恶性肿瘤、恶性肿瘤放射治疗 通信作者：付路宽，E-mail: fulukuan1202@163.com
更新日期/Last Update: 2016-06-27