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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

期数:

2016年04期

页码:

391-395

栏目:

论著

出版日期:

2016-06-27

文章信息/Info

Title:

Clinical study of cyclosporine A iontophoresis for the treatment of dry eyes

作者:

杨成明;  吴秀梅

深圳市南山区西丽人民医院，广东深圳518055

Author(s):

YANG Cheng-ming;  WU Xiu-mei

Xili People's Hospital of Shenzhen Nanshan District, Shenzhen, Guangdong 518055, China Corresponding author: YANG Cheng-ming,E-mail：ycm0419@163.com

关键词:

环孢霉素A; 离子导入; 干眼症

Keywords:

Cyclosporin A;  Iontophoresis;  Dry eye

分类号:

R777.34

DOI:

-

摘要:

目的探讨环孢霉素A 离子导入治疗干眼症的临床疗效。方法选取深圳市南山区西丽人民医院 2010 年1 月-2013 年1 月门诊收治的按照国际干眼症研究组(DEWS)标准分级为2、3 级干眼病患者100 例 (200 只眼)，按级分层后随机分为两组：对照组100 只眼予以0.22%卡波姆眼用凝胶治疗，4~6 次/d；观察 组100 只眼在对照组治疗基础上给予环孢霉素A 离子导入治疗。观察治疗前及治疗2、4、6、8 周后患者 的自觉症状、角膜荧光素染色(FL)、眼表炎症体征、泪膜破裂时间（BUT）、Sehirmer I 试验(SIt)及眼压， 并在治疗前及治疗后第8 周行结膜印迹细胞检测。结果治疗后2 周两组患者不适主诉较治疗前均明显好 转， 症状总分平均值明显降低， 两组治疗4、6、8 周后分别与其治疗前及治疗2 周后总分平均值之间比 较，差异有统计学意义(P<0.05)；治疗2、4、6 周后观察组较对照组症状总分平均值低，差异有统计学意 义(P<0.05)。观察组治疗8 周后、对照组治疗6 周后较治疗前平均BUT 延长， 差异有统计学意义(P< 0.05)。观察组和对照组治疗8 周后，平均杯状细胞密度分别为(348.6±22.5)和(360.4±27.8)个/mm2，与治疗 前比较差异有统计学意义(P<0.05)。结论环孢霉素A 离子导入治疗能够明显减轻干眼结膜炎症，降低了 滴眼剂的眼表毒性反应。

Abstract:

Objective To evaluate the clinical efficacy of cyclosporine A iontophoresis treatment of dry eye. Methods According to international dry eye Study Group (DEWS) standard rating, patients (200 eyes) with 2,3-grade dry eyes were selected from Xili People’s Hospital of Shenzhen Nanshan District from January 2010 to January 2013, and they were randomly divided into two groups. The control group of 100 eyes were treated with 0.22% carbomer eye gel, 4 to 6 times per day; the observation group of 100 eyes were treated wth cyclosporin A iontophoresis on the basis of the control group. Symptoms, corneal fluorescein staining (FL), ocular inflammation signs, tear film break- up time (BUT), Sehirmer I test (SIt) and intraocular pressure, conjunctival impression cytology were observed and measured before and after treatment. Results After 2 weeks of treatment, complains of discomfort in two group were significantly improved compared with before treatment, and the average symptom scores decreased significantly. The average scores of the two groups after 4, 6, 8 weeks treatment were statistically lower than before treatment and after 2 weeks treatment (P<0.05). There were differences between the observation group and the control group after 2, 4, 6 weeks treatment (P<0.05). Compared with before treatment, BUT extended significantly in the observation group after 8 weeks treatment and in the control group after 6 weeks treatment (P<0.05). After 8 weeks treatment, the average goblet cell density in the observation group and control group was (348.6 ± 22.5) and (360.4 ± 27.8) cells/mm2, both them were statistically significant with those before treatment (P<0.05). Conclu-sions Cyclosporine A iontophoresis therapy can significantly reduce the symptoms of dry eye conjunctivitis and ocular toxicity of eye drops.

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备注/Memo

备注/Memo:

基金项目：深圳市科技研发基金 作者简介：杨成明，博士，副主任医师，研究方向：眼表疾病的诊治 通信作者：杨成明，E-mail: ycm0419@163.com

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更新日期/Last Update: 2016-06-27