|本期目录/Table of Contents|

[1]宋海娟,黄胜利,黄卫红.幽门螺杆菌感染对高血压患者血清胃蛋白酶原的影响[J].慢性病学杂志,2016,(02):158-161.
　SONG Hai-juan,HUANG Sheng-li,HUANG Wei-hong.Changes of pepsinogen caused by Helicobacter pylori infection in patients with hypertension[J].,2016,(02):158-161.
点击复制

幽门螺杆菌感染对高血压患者血清胃蛋白酶原的影响(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年02期
页码:
158-161
栏目:
论著
出版日期:
2016-05-09

文章信息/Info

Title:
Changes of pepsinogen caused by Helicobacter pylori infection in patients with hypertension
作者:
宋海娟1; 黄胜利2; 黄卫红1
江苏省启东市第三人民医院（1 内科；2 检验科）， 江苏启东226200
Author(s):
SONG Hai-juan ;  HUANG Sheng-li ;  HUANG Wei-hong
The Third People’s Hospital of Qidong, Jiangsu Province 226200 Corresponding author: Song Haijuan , E-mail: songhaijuan1202@163.com
关键词:
胃蛋白酶原; 高血压; 高血压肾病; 视网膜病变; 幽门螺杆菌
Keywords:
Pepsinogen;  Hypertension;  Hypertensive nephropathy;  Retinopathy;  Helicobacter pylori
分类号:
R544.1
DOI:
-
摘要:
目的观察和分析高血压患者中幽门螺杆菌（Hp） 感染引起胃蛋白酶原（PG） 改变及其临床意义。 方法选取60 例高血压患者作为研究对象，根据其是否为Hp 感染将其分为Hp 感染组（32 例） 和非Hp 感染组（28 例），对两组患者的血压、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、胃蛋白 酶原Ⅰ/Ⅱ （PGⅠ/Ⅱ） 比值、合并高血压肾病情况、合并视网膜病变情况进行观察和比较。采用SPSS 13.0 统计软件进行统计分析，计量资料用均数±标准差（ xˉ±s） 表示，采用t 检验，计数资料用率（%） 表 示，采用χ2 检验，P＜0.05 表示差异有统计学意义。结果Hp 感染组患者的血清TG 水平、血清TC 水平 均显著高于非Hp 感染组（t=3.264 、3.853 ， P<0.05）， 而PG Ⅰ/Ⅱ 比值显著低于非Hp 感染组 （t=-5.159，P<0.05）；两组中合并高血压肾病或视网膜病变的患者的PGⅠ/Ⅱ比值均显著低于未合并高血 压肾病或视网膜病变的患者（t=2.754、2.963、3.022、3.267，P<0.05）；PGⅠ/Ⅱ比值诊断高血压患者肾 病和视网膜病变的血药浓度-时间曲线下面积（AUC） 分别为0.774 和0.883 （P<0.05）。结论Hp 感染可 导致高血压患者出现显著降低的PGⅠ/Ⅱ比值，该指标对患者合并高血压肾病、视网膜病变的发病具有提 示作用，具有较高的诊断效能，可作为早期诊断的辅助指标。
Abstract:
Objective To observe and analyze the change of pepsinogen (PG) caused by the infection of Helicobacter pylori (Hp) in patients with hypertension and its clinical significance. Methods 60 cases of patients with hypertension were selected as the research subjects and divided into the Hp infection and control group without Hp infection. There were 32 and 28 cases in the infection and control group, respectively. The blood pressure, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), PG I/II ratio, complication with hypertensive nephropathy, complication with retinopathy of the two groups were compared. Results The serum TG (t=3.264) and TC (t=3.853) of the Hp infection group were significantly higher than those of the control group (both P<0.05). And PG I/II ratio (t=-5.159) was significantly lower than that of the control group (P<0.05). The PG I/II ratio of the patients complicated with hypertensive nephropathy or retinopathy was significantly lower than that of the patients without the complication (t=2.754, 2.963, 3.022, 3.267, P<0.05) Area under the curve (AUCs) of PG I/II ratio in the diagnosis of the complication with hypertensive nephropathy and retinopathy of the patients hypertension were 0.774 and 0.883, respectively, which are significantly different(P<0.05). Conclusions The infection of Hp can lead to a significantly decreased PG I/II ratio in the patients with hypertension. This index (PG I / II ratio)can act as a indicator of complications with hypertension nephropathy and retinopathy. The index has a high diagnosis efficiency, which can be used as an auxiliary for early diagnosis.

参考文献/References:

[1] Goleg FA, Kong NC, Sahathevan R. Dialysis- treated endstage kidney disease in Libya: epidemiology and risk factors [J]. Int Urol Nephrol, 2014,46(8):1581-1587.
[2] Liu GX, Li YQ, Huang XR, et al. Smad7 inhibits AngII-me? diated hypertensive nephropathy in a mouse model of hyperten? sion [J]. Clin Sci (Lond), 2014, 127(3):195-208.
[3] Baltatu OC, Zaugg CE, Schumacher C, et al. Avosentan is protective in hypertensive nephropathy at doses not causing flu? id retention [J]. Pharmacol Res, 2014, 80(10):9-13.
[4] Wang XC, Liu CH, Chen YJ, et al. Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy [J]. Exp Ther Med, 2013, 6(5):1243-1246.
[5] Abd E, Motteleb DM, Elshazly SM. Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L- NAME in rats: role of GLP- 1 and GLP- 1 receptor [J]. Eur J Pharmacol, 2013, 720(1-3):158-165.
[6] Marin Garcia PJ, Marin- Casta?o ME. Angiotensin II- related hypertension and eye diseases [J]. World J Cardiol, 2014, 6(9): 968-984.
[7] Arichika S, Uji A, Yoshimura N. Adaptive optics assisted vi? sualization of thickened retinal arterial wall in a patient with controlled malignant hypertension [J]. Clin Ophthalmol, 2014, 8(10):2041-2043.
[8] Villalba-Pinto L, Hernández-Ortega M?, de Los Mozos FJ, et al. Massive bilateral serous retinal detachment in a case of hypertensive chorioretinopathy [J]. Case Rep Ophthalmol, 2014, 5(2):190-194.
[9] Aghdam SM, Sardari Z, Safaralizadeh R, et al. Investigation of Association between oipA and iceA1/iceA2 Genotypes of Helicobacter pylori and Gastric Cancer in Iran [J]. Asian Pac J Cancer Prev, 2014, 15(19):8295-8299.
[10] Oluwasola AO. Genetic determinants and clinico- pathological outcomes of helicobacter pylori infection [J]. Ann Ib Postgrad Med, 2014,12(1):22-30.
[11] Khan AH, Iqbal S, Fatima S. Agreement Between Serology and Histology for Detection of Helicobacter pylori Infection [J]. J Coll Physicians Surg Pak, 2014, 24(10):780-781.
[12] Onal IK. Histopathological Diagnosis of Helicobacter pylori: In? fluencing Factors [J]. J Coll Physicians Surg Pak, 2014, 24(10): 779.
[13] Mansour-Ghanaei F, Joukar F, Rajpout Y, et al. Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin- 17, Anti- Helicobacter Pylori and Anti- Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran [J]. Asian Pac J Cancer Prev, 2014, 15(18): 7635-7638.
[14] Xie C, Hu X, Liu F. Changes of serum pepsinogen I/II ratio in? duced by Helicobacter pylori infection in hypertensive patients [J]. Nanfang YiKeDaXue Xuebao, 2014, 34(8):1220-1223.
[15] Igarashi M, Nagano J, Tsuda A, et al. Correlation between the Serum Pepsinogen I Level and the Symptom Degree in Proton Pump Inhibitor-Users Administered with a Probiotic [J]. Phar? maceuticals (Basel), 2014, 7(7):754-764.
[16] Okubo M, Tahara T, Shibata T, et al. Light blue crest and ridge/villous patterns in the uninvolved gastric antrum by mag? nifying NBI endoscopy correlate with serum pepsinogen and gastric cancer occurrence [J]. Hepatogastroenterology, 2014, 61(130):525-528.

备注/Memo

备注/Memo:
作者简介：本科，住院医师，主要从事高血压内科临床工作 通信作者：宋海娟，Email：songhaijuan1202@163.com
更新日期/Last Update: 2016-04-27