|本期目录/Table of Contents|

[1]冼玉荣,唐小玲.慢性肾功能衰竭尿毒症期患者血清C反应蛋白水平及其影响因素分析[J].慢性病学杂志,2016,(01):37-40.
　XIAN Yu-rong *,TANG Xiao-ling.The analysis of C-reactive protein in patients with chronic renal failure （uremia period）and the influence factors[J].,2016,(01):37-40.
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慢性肾功能衰竭尿毒症期患者血清C反应蛋白水平及其影响因素分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年01期
页码:
37-40
栏目:
论著
出版日期:
2016-02-15

文章信息/Info

Title:
The analysis of C-reactive protein in patients with chronic renal failure （uremia period）and the influence factors
作者:
冼玉荣1; 唐小玲2
1.广东省江门市新会区人民医院，广东 江门 529100； 2.广东省汕头市中心医院，广东 汕头 515000
Author(s):
XIAN Yu-rong *; TANG Xiao-ling
*Departmentof Nephrology,XinhuiPeople’sHospital,Guangdong529100,China Correspondingauthor:XIAN Yu-rong,E-mail:saixyr@163.com
关键词:
慢性肾功能衰竭; 血液透析; 腹膜透析; C-反应蛋白
Keywords:
Chronic renal failure;  Hemodialysis;  Peritoneal dialysis;  C-reactive protein
分类号:
R692.5
DOI:
-
摘要:
目的 检测慢性肾功能衰竭（CRF）尿毒症期患者血清C反应蛋白（CRP）水平，分析其影响因 素。方法 CRF尿毒症期患者96例，其中规律透析治疗76例，血液透析（HD）41例（HD组），透析1 年21例（HD1组）、透析2年20例（HD2组）；腹膜透析（PD）35例（PD组），透析1年14例（PD1 组）、透析2年21例（PD2组）；未透析20例（非透析组）。另选健康成年人20例为正常对照组。检测各 组血清CRP水平，分析其影响因素。采用SPSS13.0及PEMS3.1 for windows 统计软件。计量资料以 （xˉ±s）表示，多组间比较采用方差分析，两组间比较采用t检验或t′检验；多元逐步回归分析相关性。 P＜0.05为差异有统计学意义。结果 HD、PD、非透析及正常对照组血清CRP水平分别为3.35（0.31~ 15.80）、3.08（0.13~14.80）、4.41（1.02~17.3）、1.37（1.00~3.02）mg/L，其他三组均较正常对照组升 高（P均<0.05）；HD1、HD2组分别为1.89（0.31~9.21）、5.59（0.66~15.80）mg/L，P<0.05；PD1、 PD2组 分 别 为2.36（0.13~13.80）、3.95（0.37~14.8）mg/L，P＞0.05。尿 毒 症 透 析 患 者 血 红 蛋 白 （Hb）、甘油三酯（TG）、铁（Fe）是CRP的影响因素（P均<0.05）。结论 CRF尿毒症透析患者血清 CRP水平增高，HD患者随着透析时间增加CRP水平增加，PD患者CRP水平与透析时间无关；Hb、 Fe、TG水平影响血清CRP水平。
Abstract:
Objective To observe the changes of serum C-reactive protein（CRP）levels in patients with chronic renal failure（CRF）, and to elucidate the influencing factors for CRP. Methods The study included 96 patients with CRF at uremia period. Among them, 20 were non-dialysis,41 were hemodialysis（HD）and 35 were peritoneal dialysis（PD）patients. The HD patients were randomly di-vide into two groups, HD1 with21 cases and HD2 with20 cases receiving 1 and 2 years of treat-ment, respectively. The PD patients were randomly divided into two groups, PD1 with14 cases and PD2 with21 cases receiving 1 and 2 years of treatment, respectively. There were also a group of 20 healthy controls. The serum CRP levels were detected in each group. The data was analyzed using the software SPSS13.0 and PEMS3.1 for Windows. Group means were compared using ANOVA and Student’s t test, with P<0.05 indicating statistically significant difference. Multiple stepwise regression analyses were performed to elucidate the influencing factors. Results HD, PD and the non-dialysis group with CRF showed significantly higher CRP levels than the normal controls, with mean CRP lev-els of 3.35（0.31-15.80）,3.08（0.13-14.80）,4.41（1.02-17.3）and 1.37（1.00-3.02）mg/L , respective-ly. HD1 group had lower CRP levels than HD2. There was no statistical difference between the PD1 and PD2 group. In all groups,CRP level showed no correlation with creatinine clearance rate（CCR） and serum creatinine（SCr）, but had correlation with hemoglobin（Hb）, Fe and triglycerides（TG）lev-els. Conclusions All patients with CRF at uremia period show significantly higher CRP levels than the normal controls. In HD but not PD group, the length of dialysis in hemodialysis patients has posi-tive correlation with CRP level. The levels of Hb, Fe and TG affect the levels of CRP.

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备注/Memo

备注/Memo:
作者简介：洗玉荣，硕士，主治医师，从事肾内科临床工作 通信作者：洗玉荣，E-mail：saixyr@163.com
更新日期/Last Update: 2016-03-18