|本期目录/Table of Contents|

[1]王昆仑,袁翎,刘杨,等.局部晚期食管鳞癌术后放化疗疗效分析[J].慢性病学杂志,2016,(01):17-20.
　WANG Kun-lun*,YUAN Ling,LIU Yang,et al.Effect of postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma[J].,2016,(01):17-20.
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局部晚期食管鳞癌术后放化疗疗效分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年01期
页码:
17-20
栏目:
论著
出版日期:
2016-02-15

文章信息/Info

Title:
Effect of postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma
作者:
王昆仑1; 袁翎1; 刘杨1; 徐晓霞1; 黄自明2
1.郑州大学附属肿瘤医院河南省肿瘤医院放疗科，郑州 450003 2.河南省肿瘤研究所，郑州 450003
Author(s):
WANG Kun-lun* ;  YUAN Ling; LIU Yang; XU Xiao-xia; HUANG Zi-ming
*DepartmentofRadiation Oncology，theAffiliated TumorHospital，Zhengzhou University，Zhengzhou453003,China Correspondingauthor: HUANGZi-ming,E-mail:petrochina007007@163.com
关键词:
食管癌; 手术; 术后放化疗
Keywords:
Esophageal carcinoma;  Surgical;  Chemoradiotherapy
分类号:
R721.4
DOI:
-
摘要:
目的 评价局部晚期食管鳞癌术后放化疗的疗效。方法 分析2002-2009年收治的食管癌术后病理 证实鳞癌（Ⅱa~Ⅲ期）患者203例，其中术后放化疗患者126例，单纯手术患者77例，比较两组的局部 复发率、远处转移率及生存率。结果 术后放化疗组的局部复发率及远处转移率（25.39%、42.65%）低于 单纯手术组(49.36%、66.23%)，P＜0.05。术后放化疗组的中位生存时间（40个月）与单纯手术组（25个 月）相比差异有统计学意义（P＜0.05）。两组的1、3、5年生存率比较，术后放化疗组（85.71%、 53.17%、27.78%)优于单纯手术组（67.53%、33.77%、20.78%），P<0.05。结论 术后应用同期放化疗可有 效提高局部晚期食管癌的长期生存。
Abstract:
Objective Evaluate the efficacy of chemoradiotherapy for locally advanced esophageal squa-mous cell carcinomaMethods A retrospective analysis of the clinical data of203 patients with esopha-geal cancer who received surgery from 2002 to 2009 was performed. The patients were divided into two groups, 126 patients receiving both surgery and postoperative chemoradiotherapy, and 77 patients receiving surgery alone. A comparison of the local recurrence rates, distant metastasis rates and survival rates between the two groups was carried out. Results The local recurrence rate and distant metastasis rate of the group receiving postoperative chemoradiotherapy（25.39%,42.65%, respectively）were signifi-cantly lower than those of the surgery alone group (49.36%、66.23%, respectively), with P＜0.05. Signif-icant difference of median survival was detected between the two groups. The 1-,3-,5-year overall survival rates were 85.7%,53.2%,27.8%, respectively, for the postoperative chemoradiotherapy group and were 67.5%,33.1%,21.2% for the surgery alone group. Conclusions Postoperative chemoradio-therapy can provide a benefit in overall survival in patients with locally advanced esophageal squamous cell carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：河南省科技计划项目（132102310109） 作者简介：王昆仑，硕士研究生，主治医师，主要从事消 化道肿瘤放射治疗 通信作者：黄自明，E-mail：petrochina007007@163.com
更新日期/Last Update: 2016-03-18