|本期目录/Table of Contents|

[1]张仕田,杨琴,赵红利.LEEP术在宫颈病变中诊断及其术后联合不同药物治疗的应用[J].慢性病学杂志,2016,(01):14-16.
　ZHANGShi-tian,YANG Qin,ZHAO Hong-li.A study of loop electrosurgical excision procedure in the treatment of 1576cases of cervical diseases[J].,2016,(01):14-16.
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LEEP术在宫颈病变中诊断及其术后联合不同药物治疗的应用(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年01期
页码:
14-16
栏目:
论著
出版日期:
2016-02-15

文章信息/Info

Title:
A study of loop electrosurgical excision procedure in the treatment of 1576cases of cervical diseases
作者:
张仕田; 杨琴; 赵红利
眉山市人民医院妇科，四川 眉山 620010
Author(s):
ZHANGShi-tian;  YANG Qin; ZHAO Hong-li
Departmentof Gynecology, MeishanPeople’sHospital,Meishan,Sichuan620010,China CorrespondingAuthor:ZHANG Shi-tian,E-mail:596841825@qq.com
关键词:
宫颈疾病; 高频电刀宫颈电圈环切术; 壳聚糖宫颈贴膜; 重组人干扰素α-2b 阴道泡腾胶囊
Keywords:
Cervical diseases;  LEEP;  Chitosan antibacterial membrane;  Recombinant human interferonα-2b vaginal effervescent capsule
分类号:
R711.74
DOI:
-
摘要:
目的 探讨高频电刀宫颈电圈环切术(LEEP术)在宫颈病变中诊断及其联合不同药物治疗的应用。方 法 回顾性分析LEEP术治疗1 576例宫颈病变患者资料,观察患者LEEP术前后的组织病理变化及术后随 访结果，并对其疗效进行分析。结果 本研究中LEEP术符合适应证的1 248例（79.19%），不符合适应证 的328例（20.81%）。术后病理相符90.98%(1 434/1 576)，不符9.01%(142/1 576)，其中0.57%(9/1 576) 病理降级，8.44%(133/1 576)升级，切缘阴性率为98.92%(1 559/1 576)。术后3个月复查LEEP术一次性 治愈率为98.48%（1 552/1 576）。联合壳聚糖宫颈贴膜止血抗感染患者（952例）的术后创面脱痂出血时 间，创面愈合时间与未使用的患者（624例）比较差异有统计学意义（P<0.05）；联合重组人干扰素α-2b 阴道泡腾胶囊抗人类乳头瘤病毒(HPV)术后6个月复查转阴率为92.04%（532/578），未使用的转阴率只有 77.83%（179/230），比较差异有统计学意义（P<0.05）。结论 LEEP术在临床上治疗宫颈病变简单，安 全、有效，有着重要的诊断和治疗价值。LEEP术后配合使用壳聚糖宫颈贴膜脱痂出血量少、并发症少， 宫颈创面愈合时间缩短；术后联合使用重组人干扰素α-2b 阴道泡腾胶囊，HPV转阴率显著提高。
Abstract:
Objective To investigate the efficacy and capability of loop electrosurgical excision procedure (LEEP) in treating cervical diseases. Methods LEEP was used in treating1 576 cases of cervical dis-eases. Histopathology changes and post-operation complication were analyzed. Results Among the 1 576 cases, 1 248 did meet the therapeutic conization criteria (79.19%), while the rest of the328 cas-es (20.81%) did not. After LEEP treatment,90.98% was consistent with pretreatment histopathology, while0.57% and8.44% was downgraded and upgraded, respectively. The area of operation margin was negative for cervical disease pathology in 98.92% of the cases. Followed up study at3 month post-op-eration indicated that the cure rate reached 98.48%. A total of952 cases in the study group were treat-ed with LEEP combined with chitosan antibacterial membrane, in comparison to the total of 624 cases in the control group receiving only LEEP. The time of vaginal discharge, bleeding and recovery had significant differences between the two groups (P<0.05). In the study group combining LEEP with the recombinant human interferon α-2b vaginal effervescent capsules, the effective rate was 92.04%, while the effective rate for the control group receiving only LEEP was 77.83%. The difference was statisti-cally significant (P<0.05). Conclusions LEEP is an effective and safe way for the treatment of cervi-cal diseases. The use of chitosan antibacterial membrane or recombinant human interferon α-2b vaginal effervescent capsule after LEEP treatment contributes to shortening the wound bleeding time and de-creasing the persistent infection rate by human papillomavirus (HPV).

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：四川省眉山市科学技术局科技计划项目（2011164） 作者简介：张仕田，研究生，主治医师，研究方向:妇科肿瘤 通信作者：张仕田，E-mail：596841825@qq.com
更新日期/Last Update: 2016-03-18