«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

期数:

2015年01期

页码:

19-22

栏目:

论著

出版日期:

2015-01-29

文章信息/Info

Title:

Analysis of risk factors and measure levels of high-sensitivity C-reactive protein and IL-17 among patients who have chronic obstructive pulmonary disease combined with type 2 diabetes

作者:

陈平¹;  张天彪²;  王彪²;  姚维凡²

1.沈阳市第四人民医院呼吸科，沈阳110031；2.中国医科大学，沈阳110011

Author(s):

CHEN Ping*;  ZHANG Tian-biao;  WANG Biao;  YAO Wei-fan

* Respiratory Department, The Fourth People's Hospital in Shenyang, Shenyang 110031, China Corresponding author: CHEN Ping, E-mail: sysy_chenping@126.com

关键词:

慢性阻塞性肺疾病; 2 型糖尿病; 高敏C 反应蛋白; 白介素17

Keywords:

Chronic obstructive pulmonary disease (COPD); Type 2 diabetes; High-sensitivity c-reactive protein (hs-CRP); IL-17

分类号:

R562

DOI:

-

摘要:

目的观察慢性阻塞性肺疾病（chronic obstructive pulmonary disease, COPD）合并2 型糖尿病（type 2 diabetes mellitus，T2DM）患者血清白介素17（IL- 17）及高敏C 反应蛋白（hs- CRP）的变化。方法选择 2012 年9 月-2014 年3 月沈阳市第四人民医院收治的T2DM 和COPD 患者作为研究对象，按所患疾病分为 A 组（单纯T2DM 患者39 例），B 组（单纯稳定期COPD 患者42 例），C 组（COPD 稳定期合并T2DM 患者37 例），D 组（COPD 急性期合并T2DM 患者31 例），并选择该院同期体检人员40 名为对照组。应用酶联免疫法 检测血清IL-17 和hs-CRP 水平，并进行血气分析及肺功能检测。采用SPSS 17.0 统计软件进行数据处理， 计量资料用（ xˉ±s）表示，组间比较采用t 检验，P＜0.05 为差异有统计学意义。结果D 组血清hs-CRP、IL- 17 水平[分别为(11.65 ± 4.28) mg/L 和(192.57 ± 42.17) ng/L]较C 组[分别为(8.16 ± 2.78) mg/L 和(164.27 ± 39.81) ng/L]明显升高（均P＜0.05）；C 组hs-CRP、IL-17 水平显著高于B 组[分别为（5.01±2.02） mg/L 和 （120.35±38.46） ng/L]，差异均有统计学意义（均P＜0.05）。B 组、C 组及D 组PaO2 水平低于对照组，PaCO2 高 于对照组，差异有统计学意义（均P＜0.05）。C 组和D 组肺功能水平均低于B 组，差异有统计学意义（P＜ 0.05）。结论COPD 合并T2DM 肺功能各项指标更差，hs-CRP、IL-17 水平更高，在疾病的进展过程中可能 存在相关性。

Abstract:

Objective To detect the level change of high-sensitivity c-reactive protein (hs-CRP) and IL- 17 among patients with chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) and to reveal the risk factors. Methods Patients from the Fourth People's Hospital in Shenyang, between September, 2012 and March, 2014, were selected for the study. There were 39 patients in simple T2DM group (Group A), 42 patients in simple stable COPD group (Group B), 37 patients in stable COPD complicated with T2DM group (Group C), 31 patients in acute COPD complicated with T2DM group (Group D), and 40 healthy routine check patients in control group. Serum hs- CRP, IL- 17, blood gas analysis, and lung function were detected for each patient. SPSS 17.0 was used to analyze ( xˉ±s ) was used for data description, and t-test was used to compare between groups. P<0.05 was used for statistical significant P-value. Results The serum hs-CRP and IL-17 level in Group D hs-CRP:［（11.65±4.28）mg/L, IL-17:（192.57±42.17）ng/L] were statistically significant higher than those in Group Chs-CRP: ［（8.16±2.78） mg/L, IL-17: （164.27±39.81） ng/L］. The serum hs-CRPand IL-17 level in Group C were statistically significant higher than those in Group B ［hs-CRP: （5.01± 2.02）mg/L, IL-17:（120.35±38.46）ng/L］. Compared with control group and Group A, Group B, Group C, and Group D respectively had significantly lower PaO2 and higher PaCO2 (P<0.05). The lung function in Group C and Group D were lower than those in group B (P<0.05). Conclusions Patients with COPD complicated with T2DM have lower lung function and higher level of hs-CRP and IL-17. There may be interaction effect between COPD and T2DM on health outcome.

参考文献/References:

[1] Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the di? agnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary ［J］． Am J Respir Crit Care Med, 2007, 176(6): 532-551.
[2］ Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcome in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary dis? ease ［J］． Thorax, 2006, 61(4): 284-289.
[3］ 中华医学会呼吸病分会慢性阻塞性肺疾病学组.慢性阻塞性肺 疾病诊治指南［J］．中华结核和呼吸杂志,2007,1( 30):35-41.
[4］ Barnes PJ. Therapy of chronic obstructive pulmonary disease ［J］．Pharmacol Ther, 2003,97: 87-94.
[5］ Adibrad M, Deyhimi P, Ganjalikhani HM, et al. Signs of the presence of Th17 cells in chronic periodontal disease ［J］． J Periodontal Res, 2012,47(4): 525-531.
[6］ Ganjalikhani HM, Ghaedi K, Andalib A, et al. Optimization of human Th17 cell differentiation in vitro: Evaluating different polarizing factors in vitro ［J］． Cell Dev Biol Anim, 2011,47 (8):581-592.
[7］ Newcomb DC, Peebles RS. Th17-mediated inflammation in asthma ［J］．Curr Opin Immunol, 2013,25(6):755-760.
[8］ Manel N, Unutmaz D, Littman DR. The differentiation of hu? man T (H)- 17 cells requires transforming growth factor- beta and induction of the nuclear receptor RORgammat ［J］． Nat Immunol, 2008,9(6):641-649.
[9］ Lu H, Liu L, Cheng H, et al. Expression of interleukin 17 and IgE， and its significance in patients with bronchial asthma ［J］．Afr J Pharm Pharmacol, 2012,6(40):2828-2831.
[10］ McAleer JP, Kolls JK. Directing traffic: IL- 17 and IL-22 co? ordinate pulmonary immune defense ［J］． Immunol Rev, 2014,260(1):129-144.
[11］ DeKruyff RH, Yu S, Kim HY, et al. Innate immunity in the lung regulates the development of asthma ［J］． Immunol Rev, 2014,260(1):235-48.
[12］ Morishima Y, Ano S, Ishii Y, et al. Th17- associated cyto? kines as a therapeutic target for steroid- insensitive asthma ［J］．Clin Dev Immunol, 2013:609395.
[13］ 何威,张宇.前白蛋白与C 反应蛋白在老年AECOPD 患者中的 应用［J］．临床肺科杂志,2010,15( 8) :1106-1107.
[14］ Wu W, Li Q, Xia J, et al. Effects of the glucose-lowering rate on cTnI and hs- CRP serum levels in type 2 diabetics ［J］． Hum Immunol, 2013, 74(3): 379-82.
[15］ Uslu S, Kebap?i N, Kara M, et al. Relationship between adi? pocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus ［J］． Exp Ther Med, 2012, 4(1): 113- 120.

备注/Memo

备注/Memo:

作者简介：陈平，硕士，主治医师，主要从事呼吸系统疾病的基础及临床研究工作 通信作者：陈平，E-mail：sysy_chenping@126.com

常用功能

更新日期/Last Update: 2015-01-15