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[1]韩雅蕾,陈传军,易忠,等.基线尿酸及NT-proBNP 水平与心房颤动的射频消融复发率关系的研究[J].慢性病学杂志,2015,(02):146-149.
　HAN Ya-Lei,CHEN Chuan-Jun,YI Zhong,et al.Correlation of serum uric acid and n-terminal probrain natriuretic peptide (NT-proBNP) levels with atrial fibrillation recurrence after radio-frequency ablation[J].,2015,(02):146-149.
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基线尿酸及NT-proBNP 水平与心房颤动的射频消融复发率关系的研究(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2015年02期
页码:
146-149
栏目:
论著
出版日期:
2015-04-30

文章信息/Info

Title:
Correlation of serum uric acid and n-terminal probrain natriuretic peptide (NT-proBNP) levels with atrial fibrillation recurrence after radio-frequency ablation
作者:
韩雅蕾;  陈传军;  易忠;  张萌;  靳维华
航天中心医院心脏病诊疗科，北京100039
Author(s):
HAN Ya-Lei;  CHEN Chuan-Jun;  YI Zhong;  ZHANG Meng;  JIN Wei-Hua
Center of Heart, Central Hospital of China Aerospace Corporation, Beijing 100039, China Corresponding author: HAN Ya-Lei, E-mail: over2@126.com
关键词:
心房颤动; 射频消融; 血尿酸; Ｂ型和钠肽
Keywords:
Atrial fibrillation;  Radio-frequency ablation;  Serum uric acid;  Brain natriuretic polypeptide
分类号:
R541.7
DOI:
-
摘要:
目的探讨传统的生物学标记物，如NT-proBNP 和血尿酸（SUA） 与心房颤动射频消融术后心律 失常复发的关系。方法随机入选2013 年1 月至2014 年10 月间在航天中心医院接受第一次心脏心房颤动 射频消融术的61 例患者的临床资料。其中阵发性心房颤动（持续时间<7 d） 患者39 例（63.9%），持续性 心房颤动（7 d< 持续时间<1 年） 13 例（21.3%）， 永久性心房颤动（持续时间>1 年） 的患者9 例 （14.8%）。检测各组NT-pro BNP 和SUA 水平。结果复发组与未复发组分别为13 例（21.3%） 和48 例 （78.7%）。与未复发组比，复发组患者年龄、左房前后径、冠心病比例、吸烟史比例及既往心房颤动时间 均更高；入院时NT-pro BNP 和SUA 水平均更高（P<0.01）。NT-proBNP 和SUA 水平与消融术后心房 颤动的复发呈正相关（r 分别为0.46、0.32，P＜0.05）。结论NT-proBNP 的升高提示心室张力增加或存 在心房限制性疾病，是消融术后复发的可能原因。SUA 具有促炎、促氧化作用，提示炎症和氧化应激在消 融术后的复发可能起重要作用。
Abstract:
Objective To observe the relationship between Serum Uric Acid (SUA), N-Terminal Probrain Natriuretic Peptide (NT-proBNP) levels and recurrence of lone Atrial Fibrillation (AF) after radiofrequency ablation. Methods 61 patients with lone AF at Central Hospital of China Aerospace Corporation were included in the study aftertheir initial ablation procedure from January 2013 to October 2014. These patients included 39 paroxysmal AF patients (63.9% ), 13 persistent AF patients (21.3% ) and 9 permanent AF patients (14.8%). The serum NT-pro BNP and SUA levels were measured. SUA and NT-proBNP tests were conducted within patients. Results There were 13 cases having AF recurrence (21.3%) and 48 cases (78.7%) without AF recurrence. Compared to control group, mean age,left atrium diameter, coronary heart disease, smoking, and former duration of AF were significantly higher in AF recurrence group, and the SUA and NT-proBNP levelsat the time patients admitted were also higher (P<0.01).The SUA and NT-pro BNP levels were positively associated with AF recurrence (r＝0.46, r= 0.32, P<0.05). Conclusions ElevatedSUA levels may indicate increased stress on cardiac chamber and/or intrinsic atrial disease, thus it could be a possible cause of increasing risk of arrhythmia recurrence. Because of the proinflammatoryand prooxidanteffect of SUA, inflammation and oxidation stress could play important rolesfor recurrence after radio-frequency ablation.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金资助项目（81100143）；北京市教委重点项目（KZ201110025031）；首都临床特色应用研究重 点项目（Z0005190042811）；北京市科技新星项目（Z121107002512053） 作者简介：韩雅蕾，医学博士，主治医师，研究方向为高血压疾病及心脏危重症的诊断和治疗 通信作者：韩雅蕾，E-mail: over2@126.com
更新日期/Last Update: 2015-04-15