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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

期数:

2015年02期

页码:

142-145

栏目:

论著

出版日期:

2015-04-30

文章信息/Info

Title:

Associations between left-ventricular systolic function and arterial calcifications in elderly patients with type II diabetes mellitus

作者:

王征;  朱昀;  郭晓斌;  邱萌;  王晓薏;  张福春

北京大学第三医院，北京100191

Author(s):

WANG Zheng;  ZHU Yun;  GUO Xiao-Bin;  QIU Meng;  WANG Xiao-Yi;  ZHANG Fu-Chun

The Third Hospital of Peking University, Beijing 100191, China Corresponding author: ZHANG Fu-Chun, E-mail: Zhang.fuchun@medmail.com.cn

关键词:

2 型糖尿病; 踝臂指数; 肱踝脉搏波传导速度; 左室射血分数

Keywords:

Type 2 diabetes mellitus (T2DM);  Ankle-Brachial Index (ABI);  Brachial-ankle Pulse Wave- Velocity (baPWV);  Left ventricular eject fraction

分类号:

R541.4；R587.1

DOI:

-

摘要:

目的通过回顾性分析糖尿病和非糖尿病人群中代表外周动脉硬化及僵硬度程度的肱踝脉搏波传导速 度（baPWV）、踝臂指数（ABI）） 与心脏收缩功能之间的相关性，探讨糖尿病对大血管及心脏收缩功能 的影响。方法入组糖尿病患者48 例，非糖尿病人群90 例，均接受baPWV、ABI 及超声心动图检查，并 留取血脂、糖化血红蛋白（HbA1c） 等相关临床资料。应用spearman 相关分析各观察指标之间的相关性。 结果基线资料比较显示，两组性别比例、血脂、尿酸水平差异均无统计学意义（P>0.05），HbA1c、年龄 差异有统计学意义（P<0.05）；ABI、baPWV 差异有统计学意义（P<0.05）。心功能方面，左室射血分数 （LVEF）、缩短分数（FS） 差异无统计学意义（P>0.05）。组内分析显示，糖尿病组ABI 与年龄、LVEF、 HbA1c 之间存在相关性（相关系数r 分别为0.67、0.42、0.47）；baPWV 与年龄、BMI、HbA1c 及LVEF 呈 正相关（r 分别为0.69、0.51、0.56、0.44）。非糖尿病组ABI 同样与年龄、LVEF 具有相关性（r 分别为 0.64、0.45）；baPWV 与年龄、BMI、LVEF 具有相关性（r 分别为0.64、0.55、0.45）。结论无论在糖尿 病还是非糖尿病人群中，ABI、baPWV 均与左室收缩功能的指标LVEF 呈正相关性，即左室收缩功能受到 外周动脉硬化及僵硬度的影响。

Abstract:

Objective To evaluate the associations between arterial calcifications and arterial stiffness, representing by brachial- ankle Pulse Wave- Velocity (baPWV) and Ankle- Brachial Index (ABI), and cardiac systolic function among patients with or without Type 2 Diabetes Mellitus (T2DM); to explore the effects of T2DM on great vessels and cardiac systolic function through retrospective analysis. Methods 48 patients diagnosed as T2DM were enrolled in the case group and 90 patients without T2DM were included in the control group. All patients received echocardiography, baPWV and ABI test. Medical histories and laboratory examinations such as HbA1c were collected too. Spearman’s correlation was used to detect the associations between different variables within groups. Results According to the baseline data, there were no significant differences between two groups on gender, serum lipid levels and uric acid (P>0.05), and there were statistically significant differences on HbA1c, age, ABI, and baPWV (P<0.05). For cardiac systolic function, there were no significant differences between different groups on left ventricular ejection fraction (LVEF) and fractional shortness (FS) (P>0.05). Within groups, the correlations of ABI with age, LVEF and HbA1c were significant among patients with T2DM (r was 0.67, 0.42, 0.47 respectively) (P<0.05); the correlations of baPWV with age, BMI,HbA1c, and LVEF were significant among T2DM patients (r was 0.69, 0.51, 0.56, 0.44 respectively) (P<0.05). In the control group, the correlations of ABI with age and LVEF were significant (r was 0.64, 0.45 respectively) (P<0.05); the correlations of baPWV with age, BMI, and LVEF were significant (r was 0.64, 0.55, 0.45 respectively) (P<0.05). Conclusions ABI and baPWV were associated with LVEF, which is an indicator of left- ventricular systolic function, among both patients with or without T2DM. This means the situations of arterial calcifications and arterial stiffness could influence the left-ventricular systolic function.

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备注/Memo

备注/Memo:

作者简介：王征，博士，主治医师，研究方向为老年心血管疾病、结构性心脏病。 通信作者：张福春，Zhang.fuchun@medmail.com.cn

常用功能

更新日期/Last Update: 2015-04-15