|本期目录/Table of Contents|

[1]郭永宏.地塞米松对儿童重症社区获得性肺炎的疗效分析[J].慢性病学杂志,2014,(05):341-343.
　GUO Yong-hong.Effects of dexamethasone on severe community acquired pneumonia in children[J].,2014,(05):341-343.
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地塞米松对儿童重症社区获得性肺炎的疗效分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年05期
页码:
341-343
栏目:
论著
出版日期:
2014-06-29

文章信息/Info

Title:
Effects of dexamethasone on severe community acquired pneumonia in children
作者:
郭永宏
四川省成都市妇女儿童中心医院，四川成都631000
Author(s):
GUO Yong-hong
ChengduWomen’s &Children’sCentral Hospital,Chengdu, Sichuan610017,China Correspondingauthor:GUOYang-hong，E-mail:guoyh924@163.com
关键词:
重症社区获得性肺炎; 地塞米松; 儿童
Keywords:
Severe community acquired pneumonia;  Dexamethasone;  Children
分类号:
R725.6
DOI:
-
摘要:
目的 探讨地塞米松对儿童社区获得性肺炎（CAP）的疗效。方法 选择2010年1月~2012年6月 重症CAP患儿120例，随机分为试验组和对照组，试验组62例，对照组58例。2组均给予常规治疗，试 验组在常规治疗基础上加用地塞米松，2组疗程均为3 d。比较2组治疗前后各生理学参数及实验室指标、 60 d死亡率、住院时间及不良反应。采用SPSS13.0统计软件对结果进行t检验、非参数秩和检验、χ 2检 验或Log Rank检验，P≤0.05为差异有统计学意义。结果 治疗后2组体温（T）、呼吸频率（RR）、心 率（HR）、白细胞（WBC）、中性粒细胞（NEU）及C-反应蛋白（CPR）降低，氧分压（PO2）升高，与 治疗前比较差异有统计学意义（P均<0.05）；治疗后试验组T、RR、HR、NEU及CPR降低，PO2增加， 与对照组比较差异有统计学意义（P均<0.05）。试验组60 d死亡率为11.3%（7/62），对照组15.5%（9/ 58），差异无统计学意义（P>0.05）。试验组中位数住院时间为13（11，15）d，对照组16（14，18）d， 差异有统计学意义（P=0.041）。2组不良反应比较，差异无统计学意义（P>0.05）。结论 地塞米松可以减 轻重症CAP患儿的症状和全身炎症反应，缩短住院时间，但不能降低死亡率。
Abstract:
Objective To investigate the effect of dexamethasone on children with severe community ac-quired pneumonia (CAP). Methods A total of120 children with severe CAP were divided randomly into treatment group and control group. Two groups were given conventional treatment, treatment group added dexamethasone. The treatment course was 3 days. Physiological and laboratory parameters before and after treatment were analyzed, mortality with 60 days, length of stay and side effect were com-pared between two groups. Results Compared with before treatment, after treatment body temperature, respiratory rate, heart rate, WBC, NEU, and C reactive protein (CRP) decreased, whereas PO2 in-creased in both groups (all P<0.05). After treatment, treatment group had lower body temperature, re-spiratory rate, heart rate, WBC, NEU and CRP, whereas a higher PO2 level than control group. In-hospital mortality within 60 days and side effect were not different between two groups (all P>0.05). Median length of hospital stay was significantly shorter in the treatment group compared with in the control group (13 vs. 16 days, P<0.05). Conclusions Dexamethasone can relieve symptoms and attenu-ate systematic inflammatory response, as well as reduce the length of hospital stay in children with se-vere CAP. But it can not decrease the mortality in severe CAP children.

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备注/Memo

备注/Memo:

作者简介：郭永宏，大学本科，主治医师，主要从事小儿 心脏内科工作
通信作者：郭永宏，E-mail: guoyh924@163.com
更新日期/Last Update: 2014-05-30