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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

期数:

2014年05期

页码:

324-327

栏目:

论著

出版日期:

2014-06-29

文章信息/Info

Title:

Study of the relationship between different intervention mode and pancreaticβ-cell function in patients with type2diabetes mellitus

作者:

仲维莉¹; 张春玲²; 任那¹; 邹国良¹

1.黑龙江中医药大学附属第一医院，黑龙江哈尔滨150040；
2.黑龙江中医药大学，黑龙江哈尔滨150040

Author(s):

ZHONG Wei-Li * ; ZHANG Chun-ling; Ren Na; ZOU Guo-Liang

ZHONG Wei-Li * ,ZHANG Chun-ling,Ren Na,ZOU Guo-Liang

关键词:

糖尿病; 2型; 胰岛β细胞功能; 干预方式

Keywords:

Diabetes mellitus;  type2;  Pancreatic β-cell function;  Intervention mode

分类号:

R587.1

DOI:

-

摘要:

目的 分析2型糖尿病患者不同干预方式与胰岛β细胞功能的关系。方法 2型糖尿病住院患者710 例，出院空腹血糖水平均<7.0 mmol/L，根据不同干预方式分为3组，即口服药组232例、胰岛素组174 例、胰岛素加口服药组304例，比较各组年龄、病程、体质量指数（BMI）、腰臀比（WHR）、血压、血 脂、糖化血红蛋白（HbA1C）、糖化血清蛋白（Gsp）、OGTT试验等，用Homa-IR评估胰岛素抵抗，用校 正Homa-β与△I30/△G30（去除IR的影响）、胰岛素曲线下面积、C肽曲线下面积、处置指数（DI）评估 胰岛β细胞功能。采用SPSS16.0统计软件进行方差分析、协方差分析。结果 口服药组Homa-IR低于胰 岛素加口服药组及胰岛素组（P均<0.05），校正△I30/△G30、胰岛素曲线下面积及C肽曲线下面积高于胰 岛素组及胰岛素加口服药组（P均<0.01）。3组间校正Homa-β、DI比较差异均有统计学意义（P均< 0.01），均呈现口服药组>胰岛素组>胰岛素加口服药组趋势。结论 可以根据2型糖尿病患者胰岛β细胞分 泌功能及个体组织胰岛素敏感性胰岛β细胞功能的代偿程度，选择最佳干预方式控制血糖。

Abstract:

Objective To analyse the relationship between different intervention mode and pancreaticβ-cell function in patients with type 2 diabetes. Methods 710 patients with type two diabetes whose fast-ing blood glucose were under 7.0 mmol/L when they left hospital. According to different intervention mode, patients were divided three groups, oral antidiabetic drugs group (n=232), insulin group (n=174) and insulin combined oral antidiabetic drugs group (n=304). Compare age, course, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBp), diastolic blood pressure (DBp), blood fat, glycosylated hemoglobin (HbA1C), glycosylated serum protein (Gsp), oral glucose tolerance test (OGTT) and so on among three groups. Use Homa-IR to appraisal insulin resistance and apply correct-ed Homa-β, corrected △I30/△G30, area under curve of insulin, area under curve of C-peptide and desposition index (DI) to evaluate β-cell function. SPSS16.0 was uesed for daa analysis. Results Homa-IR in oral antidiabetic drugs was lower than that in insulin group and insulin combined oral anti-diabetic drugs group (all P<0.05), corrected △I30/△G30, area under curve of insulin and area under curve of C-peptide, were obviously higher than insulin group and insulin combined oral antidiabetic drugs group (all P<0.01). The difference of corrected Homa-β and DI among three groups had statisti-cal significance (all P<0.01). Conclusions According to pancreaticβ-cell function and insulin sensitivity of individual tissue,we may to select the best intervention mode to control blood glucose in patients with type2diabetes.

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备注/Memo

备注/Memo:

基金项目：黑龙江省博士后资助基金（LRB11-365）；黑龙江省自然科学基金项目（h201325）
作者简介：仲维莉，博士，主治医师，主要从事内分泌中西医结合临床及研究工作
通信作者：邹国良，E-mail:zouguoliang198118@163.com

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更新日期/Last Update: 2014-05-30