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[1]葛畅,许春伟.涎腺成涎细胞瘤1例临床病理分析及文献复习[J].慢性病学杂志,2014,(02):119-122.
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涎腺成涎细胞瘤1例临床病理分析及文献复习(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年02期
页码:
119-122
栏目:
专题报道
出版日期:
2014-03-20

文章信息/Info

Title:
-
作者:
葛畅; 许春伟
北京军区总医院病理科, 北京100700
Author(s):
-
关键词:
成涎细胞瘤; 涎腺;  病理学; 免疫组化
Keywords:
-
分类号:
R739.86
DOI:
-
摘要:
为探讨成涎细胞瘤(sialoblastoma)的临床病理学特点。本文总结了1例成涎细胞瘤的临床表现、影像学、 病理学及免疫组化等特点，并复习相关文献进行讨论。患者颈部超声检查报告为左侧颈部实性占位，行涎腺 CT检查报告为左侧涎腺肿物；镜下肿瘤：涎腺肿瘤细胞为实质性病变，成涎细胞瘤由基底样上皮细胞构 成，肿瘤细胞质少，核圆形或椭圆形；也可见稍成熟的有粉红色胞质的立方上皮细胞；肿瘤中，上皮细胞 多形成细胞巢或上皮岛，也可形成筛孔样结构及导管样结构；也可见更成熟的涎腺结构如腺样囊性筛孔 区；细胞巢周边细胞可呈栅栏状排列，有时可见大量扭曲导管及排列紊乱的分化腺泡；核分裂易见；免疫 组织化学染色显示肿瘤细胞：Ki-67增值指数10%~15%、Vimentin（+++）、SMA（局部+）、CK14（部 分+）、S-100（+）、p53（+）、p63（+）、AE1/AE3（+）、CK7（+）、CK5/6（+）、Her-2（+），而 GFAP、Calponin、CD10、CD117、AFP等均为（-）。成涎细胞瘤是一种发生在涎腺或颌下腺罕见的潜 在侵袭性肿瘤，其确诊主要依靠组织病理学检查和免疫组化检查。治疗方法一般为手术完整切除，很少采 用放化疗。儿童期且局限的成涎细胞瘤预后一般较好。
Abstract:
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参考文献/References:

[1]Ozdemir I, Simsek E, Silan F,et al. Congenital sialoblastoma (embryoma) associated with premature centromere division and highlevelofalpha-fetoprotein［J］．PrenatDiagn,2005,25(8): 687-689.
[2］Saffari Y, Blei F, Warren SM,et al. Congenital minor sali? vary gland sialoblastoma: a case report and review of the litera? ture［J］．FetalPediatrPathol,2011,30(1):32-39.
[3］Vawter GF, Tefft M. Congenital tumors of the parotid gland ［J］．Arch Pathol,1966,82(3):242-245.
[4］黄晓峰,丁洁,胡勤刚,等.2489例涎腺上皮性肿瘤临床病理分 析［J］．口腔医学研究,2012,28(1):68-71.
[5］Saribeyoglu ET, Devecioglu O, Karakas Z,et al. How to manage an unresectable or recurrent sialoblastoma［J］．Pedi? atrBlood Cancer,2010,55(2):374-376.
[6］Vidyadhar M, Amanda C, Thuan Q,et al. Sialoblastoma［J］． J PediatrSurg,2008,43(10):e11-e13.
[7］Ersoz S, Turgutalp H, Cobanoglu U,et al. Sialoblastoma in the parotid gland: a case report［J］．Pediatr Int,2010,52(4): 670-672.
[8］Shan XF, Cai ZG, Zhang JG,et al. Management of sialoblas? toma with surgery and brachytherapy［J］．Pediatr Blood Can? cer,2010,55(7):1427-1430.
[9］Prigent M, Teissier N, Peuchmaur M,et al. Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery［J］．Int J Pediatr Oto? rhinolaryngol,2010,74(8):942-945.
[10］KattoorJ, Baisakh MR, Mathew A,etal.Sialoblastoma:a rare salivary gland neoplasm［J］．Indian J Cancer, 2010,47(2): 219-220.
[11］Patil D T, Chou PM. Sialoblastoma: utility of Ki-67and p53 as a prognostic tool and review of literature［J］．Pediatr Dev Pathol,2010,13(1):32-38.
[12］Mertens F, Wahlberg P, Domanski HA. Clonal chromosome aberrations in a sialoblastoma［J］．Cancer Genet Cytogenet, 2009,189(1):68-69.
[13］Marucci DD, Lawson K, Harper J,et al. Sialoblastoma aris? ing in ectopic salivary gland tissue［J］．J Plast Reconstr Aes? thetSurg,2009,62(8):e241-e246.
[14］Scott JX, Krishnan S, Bourne AJ,et al. Treatment of meta? static sialoblastoma with chemotherapy and surgery［J］．Pedi? atrBlood Cancer,2008,50(1):134-137.
[15］Brandwein M, Al-Naeif NS, Manwani D,et al. Sialoblasto? ma: clinicopathological/immunohistochemical study［J］．Am J Surg Pathol,1999,23(3):342-348.
[16］Som PM, Brandwein M, Silvers AR,et al. Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tu? mor［J］．AJNR Am J Neuroradiol,1997,18(5):847-850.
[17］Siddiqi SH, Solomon MP, Haller JO. Sialoblastoma and hepa? toblastoma in a neonate［J］．Pediatr Radiol,2000,30(5):349-351.
[18］Farooqi K M, Kessel R, Brandwein-Gensler M,et al. Sialo? blastoma- long-term follow-up and remission for a rare sali? vary malignancy［J］．Rare Tumors,2011,3(2):e13.
[19］Cristofaro M, Giudice A, Amentea M,et al. Diagnostic and therapeutic approach to sialoblastoma of submandibular gland: a case report［J］．J Oral Maxillofac Surg, 2008,66(1):123-126.
[20］Ben-Izhak O, Laster Z, Akrish S,et al. The salivary tip of the p53mutagenesis iceberg: novel insights［J］．Cancer Biomark, 2009,5(1):23-31.
[21］Yekeler E, Dursun M, Gun F,et al. Sialoblastoma: MRI find? ings［J］．PediatrRadiol,2004,34(12):1005-1007.
[22］Papaioannou G, Sebire N J, McHugh K. Imaging of the unusu? alpediatric'blastomas'［J］．CancerImaging,2009(9):1-11.
[23］Dardick I, Daley TD, McComb RJ. Sialoblastoma in adults: distinction from adenoid cystic carcinoma［J］．Oral Surg Oral Med OralPatholOralRadiolEndod,2010,109(1):109-116.
[24］Wang L, Chen WL, Chen JF,et al. Surgical excision of sialo? blastoma in the parotid gland in newborn［J］．Int J Pediatr Otorhinolaryngol,2013,77(8):1268-1271.

备注/Memo

备注/Memo:
作者简介：葛畅，硕士，主治医师，主要从事肿瘤病理学研 究工作 通信作者：许春伟，E-mail：xuchunweibbb@163.com
更新日期/Last Update: 2014-07-07