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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

期数:

2014年02期

页码:

88-90

栏目:

论著

出版日期:

2014-03-20

文章信息/Info

Title:

Analysis the clinicopathologic characteristics and evaluate treatment choice of colorectal neuroendocrine tumor

作者:

王壮; 周宇

广东医学院附属医院消化内科，广东广州524001

Author(s):

WANGZhuang;  ZHOUYu

DepartmentofGastroenterology,GuangdongMedicalCollege Affiliated Hospital,Guangzhou，Guangdong524001,China Correspondingauthor：WANG Zhuang，E-mail：wangzhuang0310@yeah.net

关键词:

结直肠肿瘤; 神经内分泌; 临床病理特征

Keywords:

Colorectal carcinoma;  Neuroendocrine;  Clinicopathologic characteristics

分类号:

R735.3

DOI:

-

摘要:

目的 探讨结直肠神经内分泌肿瘤治疗选择的依据及其有效性和安全性。方法 对43例结直肠神经 内分泌肿瘤患者行外科手术和肠镜下微创手术病例进行回顾性分析。结果 结直肠神经内分泌肿瘤中肿瘤 直径≤1.0 cm时，肌层浸润率为3.7%，无淋巴结转移；肿瘤直径>2 cm时，肌层浸润率为92.86%，淋巴 结转移率为78.57%。肿瘤直径与有肌层浸润及淋巴结转移相关(P<0.01)。对瘤体直径≤1.0 cm的27例结直 肠类癌患者采用内镜下进行治疗，无明显并发症，随访1例复发。对瘤体直径>1.0 cm的16例结直肠神经 内分泌肿瘤患者进行外科手术治疗，术后进行化疗。结论 对于直径≤1.0 cm的结直肠神经内分泌肿瘤通 过内镜黏膜下层剥离治疗是一种安全有效的方法，对于直径>1.0 cm者最好选择外科手术治疗。

Abstract:

Objective To study the choice of surgical approach and the efficacy and safety of colorectal neuroendocrine tumor treatment.Methods A retrospective analysis forty-three cases of colorectal neuro-endocrine tumor specimens were managed by surgery or endoscopy. Results When colorectal neuroendo-crine tumor diameter less than 1.0 cm, inherent muscular invasion was 3.7%, and without lymph node metastasis. If neuroendocrine tumor diameter more than2.0 cm, inherent muscular invasion and lymph node metastasis rate was 92.86%,78.57% respectively. Tumor diameter related with inherent muscle in-vasive tumors and lymph node metastasis (P<0.01). There are 27 cases of tumor diameter less than 1.0 cm operated by colonoscopy, which didn’t have significant complication, following up one case recur-rent. A total of 16 cases whose tumor diameter more than 1.0 cm underwent surgery and chemothera-py. Conclusions Tumor size relates with tumor stage. For colorectal carcinoid diameter less than1.0 cm, endoscopic submucosal dissection therapy is a simply, safe and effective method. Surgical treatment is the best choice for diameter more than 1.0cm.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介：王壮，硕士，主治医师，研究方向为消化道肿瘤 通信作者：王壮，E-mail: wangzhuang0310@yeah.net

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更新日期/Last Update: 2014-07-07