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[1]梁娟英,苏国生,罗晓璐,等.高效抗反转录病毒治疗联合中药治疗艾滋病的临床疗效观察[J].慢性病学杂志,2014,(08):599-601.
　LIANG Juan-ying,SU Guo-sheng,LUO Xiao-lu,et al.Observation of the clinical treatment effect on AIDS resulting from the combination of highly active antiretroviral therapy and traditional Chinese medicine[J].,2014,(08):599-601.
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高效抗反转录病毒治疗联合中药治疗艾滋病的临床疗效观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年08期
页码:
599-601
栏目:
论著
出版日期:
2014-11-30

文章信息/Info

Title:
Observation of the clinical treatment effect on AIDS resulting from the combination of highly active antiretroviral therapy and traditional Chinese medicine
作者:
梁娟英; 苏国生; 罗晓璐; 黎建源; 韦善求; 罗顺达; 刘泽端; 黄绍标
南宁市第四人民医院，广西艾滋病临床治疗中心（南宁），南宁530023
Author(s):
LIANG Juan-ying;  SU Guo-sheng;  LUO Xiao-lu;  LI Jian-yuan;  WEI Shan-qiu;  LUO Shun-da;  LIU Zeduan;  HUANG Shao-biao
Fourth People's Hospital of Nanning, GuangXi AIDS Clinical Treatment Center(Nanning), Nanning 530023, China Corresponding author: SU Guo-sheng, E-mail: suguosheng119@126.com
关键词:
艾滋病; 高效抗反转录病毒治疗; 扶正解毒中药
Keywords:
Acquired immune deficiency syndrome;  Highly active antiretroviral therapy (HAART);  Fuzhengjiedutraditional Chinese medicine
分类号:
R587.1
DOI:
-
摘要:
目的观察高效抗反转录病毒治疗（highly active antiretroviral therapy，HAART） 联合中药治疗艾 滋病疗效。方法回顾分析南宁市第四人民医院2009 年6 月-2013 年6 月收治的200 例符合入组标准的艾 滋病患者作为观察对象， 其中观察组100 例， 对照组100 例。对照组单纯采用HAART 治疗（齐多夫定 300 mg+拉米夫定150 mg+奈韦拉平200 mg，2 次/d），观察组在对照组的基础上给予扶正解毒方中药治 疗，早晚服用。两组治疗30 d 为1 个疗程，均治疗6 个疗程。观察患者症状体征改善情况，治疗前后采用 流式细胞计数测定CD4 +，采用RT-PCR 检测病毒载量。将数据录入SPSS 17.0 软件进行统计分析，采用 t 检验或χ2 检验，P<0.05 为差异有统计学意义。结果观察组乏力、肌关节疼痛、皮肤瘙痒、气短等治疗 效果明显优于对照组，差异有统计学意义（均P<0.05）。观察组和对照组治疗后CD4 +绝对计数较治疗前升 高（均P<0.05），差异有统计学意义；观察组治疗后CD4 +绝对计数高于对照组（P<0.05），差异有统计学 意义。观察组治疗后病毒载量较治疗前降低，差异有统计学意义（P<0.05）；对照组治疗前后病毒载量差 异无统计学意义（P>0.05）。结论HAART 联合扶正解毒中药能够提高CD4 +数量，促进免疫重建，降低 病毒载量，可在临床积极推广。
Abstract:
Objective To research the effect on AIDS resulting from the combination of highly active antiretroviral therapy (HAART) and traditional Chinese medicine. Methods This study was a retrospective analysis of 200 AIDS patients who treated at Nanning Fourth People's Hospital between June 2009 and June 2013 and also met the study inclusion criteria 100 cases were assigned to observation group and 100 cases were assigned to control group. The patients in control group were given only HAART [Azidothymidine (AZT) 300 mg + Lamivudine (3TC) 150 mg + Nevirapine(NVP) 200 mg, twice per day], the patients in observation group were given Fuzhengjiedu traditional Chinese medicine on the basis of control group, twice per day. 30 d was a course of treatment, and both groups had been treated for 6 month. Symptoms and signs were observed through study. CD4 + was measured using flow cytometry method before and after treatment, and viral load were measured using RT-PCR method. SSPS 17.0was used to analyze data, t test and χ2 test was used to compare groups, and p-value<0.05 was counted as statistically significant. Result The effects of reducing fatigue, muscle and joint pain, itching, shortness of breath in observation group were significantly better than in control group (P<0.05). CD4 + counts in both groups after treatment were significantly higher than before treatment (P<0.05). CD4 + counts after treatment in observation group were significantly higher than control group (P<0.05). The viral load after treatment in observation group wassignificantly lower than before treatment (P<0.05). The viral load of the control group had no significant difference before and after the treatment (P>0.05). Conclusions HAART combined with Fuzhengjiedu medication can increase the number of CD4 + , promote immune system reconstitution, and reduce viral load in the treatment of AIDS. This strategy should be promoted in clinical.

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备注/Memo

备注/Memo:
基金项目：广西壮族自治区卫生厅自筹经费科研课题（No:Z2010166;Z2014574） ;南宁市科学研究室技术开发计划项目 （NO:20143154） 作者简介：梁娟英，大学本科，副主任技师，长期从事临床检验的工作 通信作者：苏国生，E-mail: suguosheng119@126.com
更新日期/Last Update: 2014-11-30