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[1]廖述霞,谢冬梅,罗双红,等.孟鲁司特联合丙酸氟替卡松防治儿童哮喘的临床疗效观察[J].慢性病学杂志,2014,(07):543-545.
　LIAO Shu-xia*,XIE Dong-mei,LUO Shuang-hong,et al.Evaluation of the effect of montelukast and fluticasone propionate in the treatment and prevention of childhood with asthma[J].,2014,(07):543-545.
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孟鲁司特联合丙酸氟替卡松防治儿童哮喘的临床疗效观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年07期
页码:
543-545
栏目:
论著
出版日期:
2014-08-31

文章信息/Info

Title:
Evaluation of the effect of montelukast and fluticasone propionate in the treatment and prevention of childhood with asthma
作者:
廖述霞1;  谢冬梅2;  罗双红3;  林绍琼1
1.成都市新都区中医医院，四川成都610500；2.成都市新都区妇幼保健院，四川成都610500； 3.四川大学华西第二医院，四川成都610041
Author(s):
LIAO Shu-xia*;  XIE Dong-mei;  LUO Shuang-hong;  LIN Shao-qiong
*Xindu Hospital of Traditional Chinese Medicine, Chengdu ,Sichuan 610500, China Corresponding author:LIAO Shu-xia,E-mail:1449813395@qq.com
关键词:
哮喘; 孟鲁司特; 丙酸氟替卡松; 儿童
Keywords:
Asthma;  Singulair;  Flixotide;  Child
分类号:
R562.2
DOI:
-
摘要:
目的观察孟鲁司特联合丙酸氟替卡松防治儿童哮喘的临床疗效。方法80 例哮喘患儿，随机分为 观察组40 例和对照组40 例。对照组在常规治疗基础上，给予丙酸氟替卡松吸入气雾剂，200~800 μg/d， 根据病情程度选择不同剂量，连续服用30 d；观察组在对照组的基础上口服孟鲁司特，4~5 mg/次，1 次/ d，睡前服用，连续服用30 d。比较2 组治疗后2、4 周哮喘缓解例数；临床症状缓解时间、肺部体征消失 时间；采用呼气峰流速（PEF） 仪检测PEF。所有患儿随访6 个月，统计随访期间复发情况。采用SPSS 17.0 统计软件， 计数资料采用χ2 分析， 计量资料采用t 检验。结果观察组治疗2、4 周哮喘缓解例数 （15、31 例） 均高于对照组（7、20 例）； 临床症状缓解时间（2.92±0.62） d、肺部体征消失时间（4.67± 0.68） d，均短于对照组（4.69±0.73） d、（5.98±0.56） d，差异有统计学意义(P<0.05 或P<0.01)；2 组治疗 后2 周、4 周PEF 均较治疗前升高，观察组较对照组升高更明显，差异有统计学意义(P 均<0.05)；观察组 随访6 个月的复发率（2.5%） 低于对照组（22.5%）（P<0.01）。结论孟鲁司特联合丙酸氟替卡松防治儿 童哮喘的临床疗效确切。
Abstract:
Objective To evaluate the combined usage of montelukast and fluticasone propionate in the treatment and prevention of childhood asthma. Methods A total of 80 cases with childhood asthma that met the selection criteria were randomly divided into two groups (control and observation) of equal size. Patients in the control group were administered with fluticasone propionate for 30 d using the dosage of 200- 800 mg/d according to the disease severity. Patients in the observation group were administered with fluticasone propionate similar to the control group except that additional montelukast was administered with the dosage of 4-5 mg/d for 30 d once before bedtime. The number of cases with asthma remission was measured 2 and 4 weeks post- treatment. The time of clinical symptoms improvement and pulmonary symptoms disappearance were recorded and the peak expiratory flow (PEF) were detected using a PFE meter. All patients were followed up for 6 months after treatment and the indices of recurrence were analyzed. Results The number of cases with asthma remission 2- and 4-week after the initiation of treatment in the observation group were 15 and 31, respectively, while those in the control group were 7 and 20, respectively. The differences between the control and observation groups were statistically significant (P<0.05). The time of symptoms improvement and the time of disappearance ofpulmonary signs were （2.92±0.62） d and （4.67±0.68） d, respectively, which were significantly shorter than those of control group (4.69±0.73） d and （5.98±0.56） d, with P<0.05 and P<0.01, respectively. PEF of the observation group and control group 2- and 4-week after the initiation of treatment were significantly higher than before treatment (all P<0.05). PEF of observation group of 2- and 4- week were significantly higher than the control group (all P <0.05). The recurrence rate of the observation group during the 6 months follow-up period were significantly lower than control group (P<0.05). Conclusions The combined usage of montelukast and fluticasone propionate can more effectively improve symptoms and signs, improve lung function, and reduce disease recurrence than using fluticasone propionate alone, thereby representing a better treatment of childood asthma.

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备注/Memo

备注/Memo:
作者简介：廖述霞，本科，主治医师，主要从事儿科呼吸及消化系统疾病的临床治疗工作 通信作者：廖述霞，E-mail: 1449813395@qq.com
更新日期/Last Update: 2014-08-30