|本期目录/Table of Contents|

[1]曹佳佳,陈旭,刁增利,等.慢性心力衰竭患者肝肾功能损害与NT-pro-BNP相关性分析[J].慢性病学杂志,2014,(07):519-522.
　CAO Jia-jia,CHEN Xu,DIAO Zeng-li,et al.Patients with chronic heart failure incidence of liver and kidney function damage and the NT-pro-BNP correlation analysis[J].,2014,(07):519-522.
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慢性心力衰竭患者肝肾功能损害与NT-pro-BNP相关性分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年07期
页码:
519-522
栏目:
论著
出版日期:
2014-08-31

文章信息/Info

Title:
Patients with chronic heart failure incidence of liver and kidney function damage and the NT-pro-BNP correlation analysis
作者:
曹佳佳;  陈旭;  刁增利;  黄宇玲;  李素新;  张放;  张志强;  王志军
河北联合大学附属医院心内科，河北唐山063000
Author(s):
CAO Jia-jia;  CHEN Xu;  DIAO Zeng-li;  HUANG Yu-ling;  LI Su-xin;  ZHANG Fang;  ZHANG Zhi-qiang ; WANG Zhi-jun
Department of Cardiology, Affiliated Hospital of Hebei United University, Tangshan , Hebei 063000, China Corresponding author: WANG Zhi-jun，E-mail: wzj300@163.com
关键词:
慢性心力衰竭; 肝功能损害; 肾功能不全; N-末端脑钠肽前体
Keywords:
Chronic heart failure;  Liver function damage;  Renal insufficiency;  N-terminal pro-brain natriuretic peptide
分类号:
R541.4
DOI:
-
摘要:
目的观察慢性心力衰竭（chronic heart failure，CHF） 患者肝肾功能损害发生率，探讨丙氨酸氨基 转移酶（ALT）、肌酐（Cr）、N－ 末端脑钠肽前体（N-terminal pro-brain natriuretic peptide， NT-pro- BNP） 水平与左室射血分数（LVEF） 的关系。方法回顾性分析142 例CHF 患者的临床资料， 根据 LVEF 分为两组，LVEF 降低的心衰（HF-REF） 组和LVEF 保留的心衰（HF-PEF） 组，比较两组患者 基础病因、NT-pro-BNP 水平及肝肾功能损害发生率，以及ALT、Cr、NT-pro-BNP 水平与LVEF 的相 关性。结果142 例CHF 患者中冠心病103 例（72.54%），高血压性心脏病21 例（14.79%），扩张型心肌 病9 例（6.34%），老年性瓣膜病8 例（5.63%），先天性心脏病1 例（0.72%）。HF-REF 组肝功能损害、肾 功能不全的发生率分别为49.30% 、49.30% ， HF- PEF 组分别为12.68% 、15.49% 。HF- REF 组ALT、 Cr、NT-pro-BNP 水平均高于HF-PEF 组，差异有统计学意义（P<0.05）。ALT、Cr 与NT-pro-BNP 呈 正相关（r 分别为0.545 、0.522 ， P ＜ 0.01）； ALT 、Cr 和NT-pro-BNP 与LVEF 呈负相关（r 分 别为－0.273、－0.155、－0.352，P＜0.01）。结论CHF 患者基础病因以冠心病为主，常合并肝肾功能损 害，ALT、Cr 及NT-pro-BNP 水平的高低对判断心衰的严重程度有一定的评估价值。
Abstract:
Objective To observe occurrence rate ofliver and kidney dysfunction in patients with chronic heart failure (CHF), to explore the relationship between alanine aminotransferase (ALT), creatinine (Cr), NT-pro-BNP levels and left ventricular ejection fraction (LVEF). Methods A total of 142 CHF patients were divided into two groupsaccording to LVEF: heart failure with reduced ejection fraction (HFREF) group and heart failure with preserved ejection fraction (HF-PEF) group. Underlying causes, NTpro- BNP levels and the incidences of liver and kidney dysfunction in the two groups were compared. And the correlations of ALT, Cr, NT - pro - BNP levels with LVEF were analyzed. Results There were 103 cases(72.54% ) with coronary heart disease, 21 cases (14.79% ) with hypertensive heart disease, 9 cases (6.34%) with dilated cardiomyopathy, 8 cases (5.63%) with senile valve disease, 1 case (0.72%) with congenital heart disease. The incidences of hepatic dysfunction and renal dysfunction were 49.30% and 49.30% in HF-REF group and 12.68% and 15.49% in HF-PEF group, respectively. The levels of ALT, Cr, NT-pro-BNP in HF-REF group were higher than those in HF-PEF group andthe differences were statistically significant (P<0.05). ALT and Cr were positively correlated with NTpro- BNP (r=0.545 and 0.522, respectively; all P＜0.01);ALT, Cr and NT-pro-BNP were negatively correlated with LVEF (r=－0.273, －0.155, －0.352, respectively; all P<0.01). Conclusions Coronary heart disease is the main fundamental cause of CHF patients, and CHF is often associated with liver and kidney dysfunction.The levels of ALT, Cr and NT-pro-BNP have indicativevalues for the severity of heart failure.

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备注/Memo

备注/Memo:
基金项目：唐山市科技局基金资助项目（12140209A-16） 作者简介：曹佳佳，在读硕士，研究方向为心内科疾病的诊治 通信作者：王志军，E-mail: wzj300@163.com
更新日期/Last Update: 2014-08-30