|本期目录/Table of Contents|

[1]陈文庆,闫松,金新天,等.非小细胞肺癌的基因学研究及其应用研究进展[J].慢性病学杂志,2014,(06):455-458.
点击复制

非小细胞肺癌的基因学研究及其应用研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年06期
页码:
455-458
栏目:
综述
出版日期:
2014-07-30

文章信息/Info

Title:
-
作者:
陈文庆;  闫松;  金新天;  张依军;  刘刚
吉林省肿瘤医院，吉林长春130012
Author(s):
-
关键词:
非小细胞肺癌; miRNA; DNA 甲基化
Keywords:
-
分类号:
R734.2
DOI:
-
摘要:
非小细胞肺癌（NSCLC） 是肺癌中最常见的类型，目前针对于NSCLC 的病因学在分子水平上进行了 广泛的研究，主要集中在全基因组的基因表达水平、miRNA 表达水平及DNA 甲基化水平３个方面，其中 特征miRNA 表达及特征基因甲基化谱式有望成为NSCLC 预后预测的新方法。
Abstract:
-

参考文献/References:

[1] Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005 ［J］．CA Cancer J Clin, 2005,55(1):10-30.
[2］ Beadsmoore CJ, Screaton NJ. Classification, staging and prog nosis of lung cancer ［J］．Eur J Radiol, 2003,45(1):8-17.
[3］ Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers ［J］． Nature, 2005,435(7043):834- 838.
[4］ Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets ［J］．Proc Natl Acad Sci U S A, 2006,103(7):2257-2261.
[5］ Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis ［J］． Cancer Cell, 2006,9(3):189-198.
[6］ Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function ［J］．Cell, 2004,116(2):281-297.
[7］ Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer ［J］．Nature Revi Cancer, 2006,6(4):259-269.
[8］ Wu LG, Fan JH, Belasco JG. MicroRNAs direct rapid deade? nylation of mRNA ［J］．Proc Natl Acad Sci USA, 2006,103 (11):4034-4039.
[9］ Calin GA, Sevignani C, Dumitru CD, et al. Human microR? NA genes are frequently located at fragile sites and genomic re? gions involved in cancers ［J］． Proc Natl Acad Sci USA, 2004,101(9): 2999-3004.
[10］ Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2 ［J］． Proc Natl Acad Sci USA, 2005,102(39):13944-13949.
[11］ Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA Sig? nature Associated with prognosis and progression in chronic lymphocytic leukemia ［J］． N Engl J Med, 2005,353(17): 1793-1801.
[12］ Michael MZ, O’Connor SM, van Holst Pellekaan NG, et al. Reduced accumulation of specific microRNAs in colorectal neoplasia ［J］．Mol Cancer Res, 2003,1(12): 882-891.
[13］ Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene ex? pression deregulation in human breast cancer ［J］． Cancer Res, 2005,65(16):7065-7070.
[14］ Welch C, Chen Y, Stallings RL. MicroRNA-34a functions asa potential tumor suppressor by inducing apoptosis in neuro? blastoma cells ［J］．Oncogene, 2007,26(34):5017-5022.
[15］ Takamizawa J, Konishi H, Yanagisawa K, et al. Reduced ex? pression of the let- 7 microRNAs in human lung cancers in as? sociation with shortened postoperative survival ［J］． Cancer Res, 2004,64(11):3753-3756.
[16］ Johnson SM, Grosshans H, Shingara J, et al. RAS is regulat? ed by the let- 7 microRNA family ［J］． Cell, 2005,120(5): 635-647.
[17］ Chan JA, Krichevsky AM, Kosik KS. MicroRNA- 21 is an antiapoptotic factor in human glioblastoma cells ［J］． Cancer Res, 2005,65(14):6029-6033.
[18］ Metzler M, Wilda M, Busch K, et al. High expression of pre? cursor microRNA- 155/BIC RNA in children with Burkitt lymphoma ［J］． Genes Chromosomes Cancer, 2004,39(2): 167-169.
[19］ Eis PS, Tam W, Sun LP, et al. Accumulation of miR- 155 and BIC RNA in human B cell lymphomas ［J］． Proc Natl Acad Sci U S A, 2005,102(10):3627-3632.
[20］ Kluiver J, Poppema S, de Jong D, Blokzijl T, et al. BIC and miR- 155 are highly expressed in Hodgkin, primary mediasti? nal and diffuse large B cell lymphomas ［J］． J Pathol, 2005, 207(2):243-249.
[21］ van den Berg A, Kroesen BJ, Kooistra K, et al. High expres? sion of B- cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma ［J］．Genes Chromosomes Cancer, 2003, 37(1):20-28.
[22］ He L, Thomson JM, Hemann MT, et al. A microRNA poly? cistron as a potential human oncogene ［J］． Nature, 2005,435 (7043):828-833.
[23］ Ota A, Tagawa H, Karnan S, et al. Identification and charac? terization of a novel gene, C13orf25, as a target for 13q31- q32 amplification in malignant lymphoma ［J］． Cancer Res, 2004,64(9):3087-3095.
[24］ Calin GA, Liu CG, Sevignani C, et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leuke? mias ［J］． Proc Natl Acad Sci USA, 2004,101(32):11755- 11760.
[25］ Tagawa H, Seto MA. microRNA cluster as a target of genom ? ic amplification in malignant lymphoma ［J］． Leukemia, 2005,19(11):2013-2016.
[26］ Gordon AT, Brinkschmidt C, Anderson J, et al. A novel and consistent amplicon at 13q31 associated with alveolar rhabdo? myosarcoma ［J］．Genes Chromosomes Cancer, 2000,28(2): 220-226.
[27］ Schmidt H, Bartel F, Kappler M, et al. Gains of 13q are corre? lated with a poor prognosis in liposarcoma ［J］． Mod Pathol, 2005,18(5):638-644.
[28］ Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic microRNA cluster, miR- 17- 92, is over- expressed in human lung cancers and enhances cell proliferation ［J］．Cancer Res, 2005,65(21):9628-9632.
[29］ O’Donnell KA, Wentzel EA, Zeller KI, et al. c-Myc-regu? lated microRNAs modulate E2F1 expression ［J］． Nature, 2005,435(7043):839-843.
[30］ Egger G, Liang G, Aparicio A, et al. Epigenetics in human disease and prospects for epigenetic therapy ［J］． Nature, 2004,429(6990):457-463.
[31］ Jones PA, Takai D. The role of DNA methylation in mamma? lian epigenetics ［J］．Science, 2001,293(5532):1068-1070.
[32］ Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer ［J］．Nat Rev Genet, 2002,3(6):415-428.
[33］ Bird A. DNA methylation patterns and epigenetic memory ［J］． Genes Dev, 2002,16(1):6-21.
[34］ Widschwendter M, Jones PA. The potential prognostic, pre? dictive, and therapeutic values of DNA methylation in cancer ［J］． Clin Cancer Res, 2002,8(1):17-21.
[35］ Yoo CB, Jones PA. Epigenetic therapy of cancer: past, pres? ent and future ［J］．Nat Rev Drug Discov, 2006,5(1):37-50.
[36］ Virmani AK, Tsou JA, Siegmund KD, et al. Hierarchical clustering of lung cancer cell lines using DNA methylation markers ［J］． Cancer Epidemiol Biomarkers Prev, 2002,11 (3):291-297.
[37］ Frühwald MC, Plass C. Global and gene-specific methylation patterns in cancer: aspects of tumor biology and clinical poten? tial ［J］． Mol Genet Metab, 2002,75(1):1-16.
[38］ Marchevsky AM, Tsou JA, Laird- Offringa IA. Classification of individual lung cancer cell lines based on DNA methylation markers: use of linear discriminant analysis and artificial neural networks ［J］．J Mol Diagn, 2004,6(1):28-36.
[39］ Herman JG, Umar A, Polyak K, et al. Incidence and function? al consequences of hMLH1 promoter hypermethylation in colorectal carcinoma ［J］．Proc Natl Acad Sci USA, 1998,95 (12):6870-6875.
[40］ Saito Y, Jones PA. Epigenetic activation of tumor suppressor microRNAs in human cancer cells ［J］． Cell Cycle, 2006,5 (19):2220-2222.
[41］ Chuang JC, Jones PA. Epigenetics and microRNAs ［J］．Pe? diatr Res, 2007,61(5 Pt 2):24R-29R.
[42］ Saetrom P, Snove O Jr, Rossi JJ. Epigenetics and microRNAs ［J］．Pediatr Res, 2007,61(5 Pt 2):17R-23R.
[43］ Bao N, Lye KW, Barton MK. MicroRNA binding sites in Ara? bidopsis class III HD- ZIP mRNAs are required for methyla? tion of the template chromosome ［J］． Dev Cell, 2004,7(5): 653-662.
[44］ Rajewsky N. microRNA target predictions in animals ［J］． Nat Genet, 2006(38):S8-13.
[45］ Brueckner B, Stresemann C, Kuner R, et al. The human let- 7a- 3 locus contains an epigenetically regulated microRNA gene with oncogenic function ［J］． Cancer Res, 2007,67(4): 1419-1423.
[46］ Lujambio A, Ropero S, Ballestar E, et al. Genetic unmaskingof an epigenetically silenced microRNA in human cancer cells ［J］．Cancer Res, 2007,67(4):1424-1429.
[47］ Saito Y, Liang G, Egger G, et al. Specific activation of mi? croRNA- 127 with downregulation of the proto- oncogene BCL6 by chromatin- modifying drugs in human cancer cells ［J］．Cancer Cell, 2006,9(6):435-443.
[48］ Kim VN, Nam JW. Genomics of microRNA ［J］． Trends Genet, 2006,22(3):165-173.

备注/Memo

备注/Memo:
基金项目：吉林省科技厅资助项目（201115215） 作者简介：陈文庆，硕士，副主任医师，主要从事胸部肿 瘤外科工作 通信作者：张依军，E-mail: 853455895@qq.com
更新日期/Last Update: 2014-07-30