|本期目录/Table of Contents|

[1]袁茂华.阿奇霉素联合头孢拉定治疗老年慢性阻塞性肺病效果观察[J].慢性病学杂志,2014,(03):189-191.
　YUAN Mao-hua.Clinical efficacy of azithromycin combined with cefradine on treatment of elderly chronic obstructive pulmonary diseases[J].,2014,(03):189-191.
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阿奇霉素联合头孢拉定治疗老年慢性阻塞性肺病效果观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年03期
页码:
189-191
栏目:
论著
出版日期:
2014-06-22

文章信息/Info

Title:
Clinical efficacy of azithromycin combined with cefradine on treatment of elderly chronic obstructive pulmonary diseases
作者:
袁茂华
广州市越秀区大东街社区卫生服务中心，广东广州510080
Author(s):
YUAN Mao-hua
DadongCommunity HealthServiceCenterofYuexiu District,Guangzhou,Guangdong510080,China Correspongdingauthor:YUANMao-hua,E-mail:574958373@qq.com
关键词:
阿奇霉素; 头孢拉定; 老年; 慢性阻塞性肺病
Keywords:
Azithromycin;  Cefradine;  Elderly patients;  Chronic obstructive pulmonary diseases
分类号:
R563.9
DOI:
-
摘要:
目的 观察阿奇霉素联合头孢拉定治疗老年慢性阻塞性肺病（COPD）的临床疗效。方法 选取老年 COPD患者120例，随机分为观察组和对照组，每组60例。两组患者均给予低流量持续吸氧、呼吸运动锻 炼、排痰化痰和解痉平喘等对症支持治疗。对照组患者静脉滴注头孢拉定，观察组患者在对照组的基础上 加用阿奇霉素，连续治疗7 d。比较两组患者治疗后的临床疗效和肺功能参数。结果 观察组有效率为 95.00%，对照组为83.33%，两组相比差异有统计学意义（χ 2 =4.23，P＜0.05）；治疗后观察组和对照组的 肺总量（TV）、最大通气量（MVV）、肺活量（FVC）、一秒钟用力呼气容积（FEV1）和占肺活量比值 （FEV1%）指标均高于治疗前，差异有统计学意义(P均＜0.05)；且观察组治疗后TV、MVV、FVC、 FEV1 和FEV1%指标均高于对照组治疗后，差异有统计学意义（P均＜0.05）。结论 阿奇霉素联合头孢 拉定治疗老年COPD疗效优于单独使用头孢拉定，值得在临床推广。
Abstract:
Objective To observe the clinical efficacy of Azithromycin combined with Cefradine in treat-ment of elderly chronic obstructive pulmonary diseases（COPD）. Methods120 patients who were diag-nosed with elderly COPD were assigned into intervention group and control group randomly. Both groups were given support therapies including the therapy reducing phlegm, spasmolysis and asthma, continuous low flow oxygen therapy and breathing exercise. Patients in control group were taking intra-venous injection Cefradine on the basis of support therapies; patients in intervention group were taking Azithromycin in addition to Cefradine. Clinical efficacies and lung function index were compared between these two groups after 7 days treatment. Results The effective rate of intervention group was95.00% which was higher than83.33% from control group; the difference was statistically significant (χ 2 =4.23, P＜0.05). After the treatment, the average Tidal Volume (TV), Maximal Voluntary Ventilation (MVV), Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 Second (FEV1) and Percentage of FEV1 accounting for FVC (FEV1%) of intervention group and constrol group were all statistically sig-nificant higher than before (P＜0.05) and the arerage of TV，MVV,FVC,FEV1,and FEV1% in interven-tion group were much higher than control group (P＜0.05). Conclusions Using Azithromycincombined with Cefradine in treatment of elderly COPD is more effective and relatively safe compared to using Cefradine alone.

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备注/Memo

备注/Memo:
作者简介：袁茂华，大学本科，主治医师，主要从事全科医学临床工作 通信作者：袁茂华，E-mail：574958373@qq.com
更新日期/Last Update: 2014-03-30