|本期目录/Table of Contents|

[1]李常洲,段庆华,李建辉,等.NF-κB在胃癌组织中的表达及其与TOPOⅡ和Ki-67的关系[J].慢性病学杂志,2014,(01):31-34.
　LI Chang-zhou,DUAN Qing-hua,LI Jian-hui,et al.Expression of NF-κB in gastric carcinoma and its relationship with TOPOⅡand Ki-67[J].,2014,(01):31-34.
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NF-κB在胃癌组织中的表达及其与TOPOⅡ和Ki-67的关系(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年01期
页码:
31-34
栏目:
论著
出版日期:
2014-02-25

文章信息/Info

Title:
Expression of NF-κB in gastric carcinoma and its relationship with TOPOⅡand Ki-67
作者:
李常洲; 段庆华; 李建辉; 刘海丽; 陈桂香
承德医学院附属承德市中心医院，河北承德067000
Author(s):
LI Chang-zhou;  DUAN Qing-hua;  LI Jian-hui;  LIU Hai-li;  CHEN Gui-xiang
ChengdeCentral Hospital Affiliated ofChengde MedicalCollage, Chengde, Hebei067000,China Correspondingauthor:LIChang-zhou, E-mail:changzhou20@126.com
关键词:
胃肿瘤; NF-κB; TOPOII; Ki-67; 免疫组化
Keywords:
Gastric cancer;  NF-κB;  TOPOⅡ;  Ki-67;  Immunohistochemistry
分类号:
R735.2
DOI:
-
摘要:
目的通过检测NF-κB在胃癌、癌旁增生组织及正常胃黏膜组织中的表达，探讨其与TOPOⅡ、Ki-67在胃癌中表达的相关性及意义。方法 采用免疫组织化学的方法，检测随机选取的102份胃癌石蜡标本 及相应的癌旁增生组织标本和正常胃黏膜组织，检测三者表达情况。计数资料采用χ 2检验和四格表精确概 率法，相关性分析采用Spearmen等级相关分析，P＜0.05为差异有统计学意义。结果 NF-κB蛋白在胃 癌、癌旁增生组织及正常黏膜组织中的表达率分别为70.59%（72/102）、22.22%(10/45)、5.88%（2/34）， TOPOⅡ、Ki-67在胃癌组织中均有阳性表达；NF-κB的表达与TOPOⅡ（r=0.301，P=0.002）、Ki-67 （r=0.334，P=0.001）的表达呈显著正相关。结论NF-κB和TOPOⅡ、Ki-67三者在胃癌组织中的高表达 与肿瘤浸润深度、淋巴结转移、临床分期有相关性，且三者之间存在一定的协同作用，联合检测有助于胃 癌预后的判断。
Abstract:
ObjectiveTo detecting the expression of NF-κB in gastric cancer, hyperplasia and adjacent normal gastric mucosa, and to explore the relevance of NF-κB, TOPOⅡand Ki-67. MethodsA total of 102 cases with gastric cancer were randomly selected. And their gastric cancer detection paraffin spec-imen, adjacent noncancerous tissue hyperplasia and normal gastric mucosa were measured by immunohis-tochemical methods to research the expression of NF-κB, TOPOⅡand Ki-67. ResultsThe expression of NF-κB protein in gastric cancer, hyperplasia and adjacent normal mucosa tissues was 70.59%(72/ 102), 22.20%(10/45), 5.90%(2/34), respectively. Expression of NF-κBwas singificantly positively corre-lated with TOPOⅡ(r=0.301, P=0.002), Ki-67 (r=0.334, P=0.001). ConclusionsThe high expres-sions of NF-κB, TOPOⅡand Ki-67 in gastric cancer are correlated with the depth of invasion, lymph node metastasis and clinical stage, and there is a certain synergy among the them. Combined de-tection of NF-κB, TOPOⅡand Ki-67helps the prognosis of gastric cancer analyzing.

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备注/Memo

备注/Memo:
作者简介：李常洲，在读硕士，研究方向为消化系统肿瘤的 治疗 通信作者：李建辉，E-mail:changzhou20@126.com
更新日期/Last Update: 2014-01-30