|本期目录/Table of Contents|

[1]陈良,彭孝纬.临床分离的幽门螺旋杆菌的多重耐药性的相关分析[J].慢性病学杂志,2013,(10):756-757.
　CHEN Liang,PENG Xiao-wei.Analysis of multiple drug resistance of helicobacter pylori which was separated from clinical samples[J].,2013,(10):756-757.
点击复制

临床分离的幽门螺旋杆菌的多重耐药性的相关分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2013年10期
页码:
756-757
栏目:
论著
出版日期:
2013-10-30

文章信息/Info

Title:
Analysis of multiple drug resistance of helicobacter pylori which was separated from clinical samples
作者:
陈良; 彭孝纬
福建省立医院消化内科,福建 福州 350000
Author(s):
CHEN Liang; PENG Xiao-wei
Department of Digestive Diseases,Fujian Provincial Hospital,Fuzhou,Fujian 350000,China Corresponding author:CHEN Liang,E-mail:31670456@qq.com
关键词:
幽门螺旋杆菌;  多重耐药性
Keywords:
Helicobacter pylori;  Multiple Drug Resistance
分类号:
R496.5
DOI:
-
摘要:
目的 探析本地区幽门螺旋杆菌(Hp)常用抗生素的多重耐药性,为临床提供依据以指导临床。方法 从福建省立医院2012年1月至2012年12月因上消化道症状在该院接受胃镜检查的患者胃粘膜标本中,分离培养Hp菌株,运用药敏试验对分离出的菌株行抗菌药敏感性检测。结果 Hp阳性率为31.15%,药敏试验阿莫西林、呋喃唑酮、左氧氟沙星、庆大霉素的敏感性均在88.00%以上,克拉霉素耐药率18.89%,甲硝唑耐药率100%,129株出现了对2种抗生素的混合耐药,12株出现了3种抗生素的混合耐药。结论 本地区对甲硝唑及克拉霉素的耐药率较高,临床运用也应考虑单药耐药与多重耐药。
Abstract:
Objective To explore and analyze Multiple Drug Resistance of helicobacter pylori to regular antibiotics,and to provide evidence for clinical use of antibiotics. Methods Hp strains which were isolated from the specimens of gastric mucosa from clinical samples.The clinical samples were collected from the patients who had undergone gastroscopy due to digestive symptoms in our hospital during January 2012 and December 2012.The Hp strains were cultivated and tested antibiotic sensitivity by medicine sensitive experiment. Results Hp positive rate was 31.14%.Sensitivity rate of amoxicillin,furazolidone,levofloxacin,gentamicin drug sensitive test were all above 88.00%.The drug resistant rate to clarithromycin was 18.89% and to metronidazole was 100%.129 strains showed the hybrid resistant to two kinds of antibiotics,and 12 strains had Multiple Drug Resistance to three kinds of antibiotics. Conclusions The metronidazole and clarithromycin resistant rate were high in this region,and in clinical treatment it should be paid more attention to both single drug resistance and Multiple Drug Resistance.

参考文献/References:

[1] 吕琳,罗红春,杨致邦,等.重庆地区幽门螺杆菌临床株耐药性研究[J].重庆医学,2009,38(6):669-671.
[2] 施正超,任宗海,潘小慧,等.瑞安地区上消化道疾病患者幽门螺杆菌感染及耐药情况分析[J].实用医学杂志,2009,25(20):3497-3499.
[3] 黄烈平,庄满利,顾承萍.36株青少年幽门螺杆菌耐药分析[J].中国当代儿科杂志.2009,11(3):210-212.
[4] 吕农华,祝荫.幽门螺杆菌耐药的现状与对策[J].中华消化杂志,2011,31(1):66-68.
[5] 王艳,周惠琴,唐文.苏州市胃肠病患者幽门螺旋杆菌耐药分析[J].中国公共卫生,2010,26(1):122-123.
[6] 刘元德,叶明好,卞荣兵.幽门螺杆菌耐药机制的研究进展[J].临床军医杂志,2009,37(2):314- 318.
[7] 黄宏思,俞文强,黄衍强,等.胃溃疡及胃炎患者幽门螺杆菌耐药性分析[J].中国公共卫生,2010,26(1):59-60.

备注/Memo

备注/Memo:
作者简介:陈良,硕士,副主任医师,主要从事消化系统疾病的诊治工作 通讯作者:陈良,E-mail:31670456@qq.com
更新日期/Last Update: 2013-10-30