|本期目录/Table of Contents|

[1]郝增光,杨晓红,郑晓晖,等.７６例冠状动脉慢血流患者临床观察[J].慢性病学杂志,2013,(02):101-103.
　HAO Zeng-guang,YANG Xiao-hong,ZHENG Xiao-hui,et al.Clinical observation on 76 patients with coronary slow flow[J].,2013,(02):101-103.
点击复制

７６例冠状动脉慢血流患者临床观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2013年02期
页码:
101-103
栏目:
论著
出版日期:
2013-02-28

文章信息/Info

Title:
Clinical observation on 76 patients with coronary slow flow
作者:
郝增光; 杨晓红; 郑晓晖; 杨睿; 王彦方
河南省安阳地区医院心内二科,河南 安阳 455000
Author(s):
HAO Zeng-guang; YANG Xiao-hong; ZHENG Xiao-hui; YANG Rui; WANG Yan-fang
Anyang Hospital of Henan Province,Anyang,Henan 455000,China Corresponding author:HAO Zeng-guang,E-mail:24665621@qq.com
关键词:
慢血流;  易发因素;  同型半胱氨酸;  叶酸
Keywords:
Slow flow;  Risk factors;  Homocysteine;  Folic acid
分类号:
R541.4
DOI:
-
摘要:
目的 观察分析冠状动脉慢血流的易发因素及治疗效果,为临床诊治提供参考。方法 将被诊断为冠状动脉慢血流的76例患者作为病例组,68例冠状动脉造影正常的患者作为对照组,比较两组患者各项指标之间的差异,分析慢血流的易发因素。将76例慢血流患者随机分为叶酸治疗组36例和对照治疗组40例,比较叶酸治疗的疗效。应用SPSS 16.0软件建立数据库进行统计分析。计量资料采用两样本等方差t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 冠状动脉慢血流患者中男性56例,占73.68%; 多数患者有吸烟史(40例,52.63%)、糖尿病史(18例,23.68%)和高血压病史(12例,15.79%),尿酸、同型半胱氨酸、低密度脂蛋白和高密度脂蛋白水平均高于对照组,两组差异有统计学意义(P<0.05)。叶酸治疗组临床症状有效率为70.0%,对照治疗组的有效率为40.0%,两组差异有统计学意义(P<0.05)。结论 男性、体重指数高、吸烟史、血脂水平高、尿酸值高、高同型半胱氨酸水平可能为慢血流的易发因素,叶酸治疗慢血流有一定疗效。
Abstract:
Objective To observe and analyze risk factors and treatment effect of coronary slow flow and to provide the reference for the clinical diagnosis. Methods 76 patients with coronary slow flow were taken as case group while 68 patients with normal coronary angiography as control group,and their indexes were compared in order to find out risk factors of coronary slow flow.Case group patients were randomly divided into folic acid treatment group and control treatment group with 36 cases and 40 cases,respectively.The effect of folic acid treatment was compared.SPSS 16.0 software was used to establish database for statistical analysis. Results Male patients accounted for 73.68% of all patients with coronary slow flow(56 cases).The majority of patients had a history of smoking(40 cases,52.63%),diabetes(18 cases,23.68%)and hypertension(12 cases,15.79%),Uric acid,homocysteine,low density lipoprotein and high density lipoprotein levels were higher than those of control group; there was statistically significant difference between two groups(P<0.05). Conclusions Male,high body mass index,smoking,high blood lipid level,high uric acid,homocysteine levels may be risk factors of coronary slow flow.Folic acid treatment had certain curative effect on slow flow.

参考文献/References:

[1] Tambiea A,Demany MA,Zimmenman HA,et al.Angina pectoris and slow flow velocity of dye in coronary arteries:a new angigraphic finding[J].Am Heart,1972,84:66-71.
[2] 樊瑛,杨树森,于江波,等.阿托伐他汀对冠状动脉血流缓慢患者冠状动脉血流储备的影响[J].中华心血管病杂志,2010,38(2):143-146.
[3] LI JJ,WU YJ,QIN XW.Should slow coronary flow be considered as coronary syncope?[J].Med Hypotheses,2006,66:953-956.
[4] Rim SJ,Leongpoi H,Lindner JR,et al.Decrease in coronary blood flow reserve during hyperlipidemia is secondary to an increase in blood viscosity[J].C irculation,2001.104(22):2704-2709.
[5] Erdogan D.Caliskan M,Gullu H,et al.Coronary flow reserve is impaired in patients with slow coronary flow[J].Atherosclerosis,2007,191(1):168-174.
[6] Yamashita K.Takahiro K,Kamezaki F,el al.Decreased plasma extracellular superoxide dismutase level in patient with Vasospastic angina[J].Atherosclerosis,2007,191(1):147-152.
[7」 Fairfield KM,Fletcher R.Vitamines for chronic disease prevention in adults [J]. JAMA,2002,287:3116-3126.
[8] Doshi SN,McDowel IF,Moat SJ,et al.Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?[J].Arterioscler Thromb Vasc Boil,2001,21(7):1196-1202.
[9] Stroes ES,van Faassen EE,Yo M,et al.Folic acid reverts dysfunction of endothelial nitric oxide synthase [J]. Circ Res,2000,86(11):1129-1134.

备注/Memo

备注/Memo:
作者简介:郝增光,本科,主治医师,主要从事冠心病和心力衰竭方面的研究 通讯作者:郝增光,E-mail:24665621@qq.com
更新日期/Last Update: 2014-07-08