|本期目录/Table of Contents|

[1]沈木生,王英,侯树慧,等.碱性离子水对高脂大鼠抗氧化作用的实验研究[J].慢性病学杂志,2013,(01):22-24.
　SHEN Mu-sheng*,WANG Ying,HOU Shu-hui,et al.Experimental study on antioxidant effect of alkaline ionized water on hyperlipidemia in rats[J].,2013,(01):22-24.
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碱性离子水对高脂大鼠抗氧化作用的实验研究(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2013年01期
页码:
22-24
栏目:
论著
出版日期:
2013-01-30

文章信息/Info

Title:
Experimental study on antioxidant effect of alkaline ionized water on hyperlipidemia in rats
作者:
沈木生1; 2; 王英2; 侯树慧2; 潘桂兰2; 余艳琴2
1.鄂尔多斯市血站,内蒙古 鄂尔多斯 017010; 2.包头医学院,内蒙古 包头 014030
Author(s):
SHEN Mu-sheng*; WANG Ying; HOU Shu-hui; PAN Gui-lan; YU Yan-qin *
Blood Station of Erdos City,Erdos,Inner Mongolia 017010,China Corresponding author:WANG Ying,E-mail:lbwy0160@sina.com
关键词:
碱性离子水;  高脂;  抗氧化
Keywords:
Alkaline ionized water;  Hyperlipidemia;  Antioxidant effect
分类号:
R123.6
DOI:
-
摘要:
目的 观察不同pH值的碱性离子水(alkaline ionized water,AIW)对高脂大鼠的抗氧化作用,探讨其可能的机制。方法 选用Wistar雄性大鼠60只,建立大鼠高脂血症模型,给予不同pH值AIW。将大鼠随机分为空白对照组、模型对照组(高脂)、AIW pH 8.5组、AIW pH 9.5组、AIW pH丙二醛10.5组。大鼠饲养8周结束实验,检测血清中TG、TC、HDL、LDL、MDA、SOD及肝脏的MDA含量和SOD活性。用SPSS 11.5软件对结果进行比对分析。结果 pH 8.5和pH 9.5组大鼠血清TC低于模型对照组,差异具有统计学意义(P<0.05),HDL和LDL均明显高于模型对照组,差异均有统计学意义(P<0.05),模型对照组大鼠血清和肝组织SOD活性降低,而MDA含量升高,与空白对照组比较,差异有统计学意义(P<0.01); 各AIW组大鼠血清和肝脏组织MDA含量降低,SOD活性升高,与模型对照组比较,差异有统计学意义(P<0.01)。结论 AIW可以提高机体清除氧自由基的能力,具有一定的抗氧化作用。
Abstract:
Objective To observe the antioxidant effect of alkaline ionized water(AIW)with different pH on high-fat diet rats by animal experiments, and to discuss probable mechanisms. Methods According to their body weight, 60 Wistar male rats were randomly divided into control group,model group, pH 8.5 group, pH 9.5 group and pH 10.5 group, with 12 rats in each group.After 8 weeks, rats were decapitated and serum of the rats was collected to test the levels of TG、TC、HDL、LDL、MDA and SOD.MDA level and SOD activity were tested on the livers of the rats.Statistic analysis was performed by SPSS. Results The levels of TC in serum of pH 8.5 group and pH 9.5 group were lower than the model group(P<0.05).HDL and LDL in serum were much higher than the model group(P<0.05).The activity of SOD in the serum and liver of the model group decreased significantly, while the MDA level increased(P<0.01).Compared with the model group, activity of SOD in the serum and liver of AIW groups increased, and MDA level decreased remarkably(P<0.01). Conclusions It is indicated that AIW could improve the body's ability to eliminate oxygen free radicals, therefore have certain antioxidant effects.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:内蒙古教育厅科研项目(NJZY11187) 作者简介:沈木生,硕士研究生,副主任检验技师,主要从事生物化学与分子生物学方面的研究 通讯作者:王英,E-mail:lbwy0160@sina.com
更新日期/Last Update: 2013-01-30